Catalog Number: 4092
Chemical Name: 2-Acetoxybenzoic acid
Biological Activity
Inhibitor of cyclooxygenase (COX)-1. Blocks the production of prostaglandins and thromboxanes. Exhibits antiplatelet and antithrombotic activities. Displays anticancer effects in some solid tumors. One of the first described NSAID drugs.
Technical Data
  • M.Wt:
    180.16
  • Formula:
    C9H8O4
  • Solubility:
    Soluble to 10 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    50-78-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis.
    Schror
    Semin.Thromb.Hemost., 1997;23:349
  2. Aspirin inhibits interleukin 1-induced prostaglandin H synthase expression in cultured endothelial cells.
    Sanduja et al.
    Proc.Natl.Acad.Sci., 1991;15:88
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Aspirin include:

2 Citations: Showing 1 - 2
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  1. The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation.
    Authors: Walsh Et al.
    Redox Biol 2014;2:178
  2. A novel and essential role for FcγRIIa in cancer cell-induced platelet activation.
    Authors: Mitrugno Et al.
    Blood 2014;123:249

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