R-(-)-enantiomer of gossypol
(Cat. No. 1964). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro
through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo
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All Tocris products are intended for laboratory research use only.
AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance.
Balakrishnan et al.
R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells.
Kline et al.
In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration.
Loberg et al.
The citations listed below are publications that use Tocris products. Selected citations for AT 101 include:
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