AT 101

Catalog # Availability Size / Price Qty
3367/10
3367/50
Additional Bcl-2 Family Compounds Small Molecule
1 Image
Description: Downregulates Bcl-2 and Mcl-1; pro-apoptotic

Chemical Name: (-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde

Purity: ≥98%

Product Details
Citations (1)
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Reviews

Biological Activity

R-(-)-enantiomer of gossypol (Cat. No. 1964). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo.

Technical Data

M.Wt:
518.56
Formula:
C30H30O8
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
90141-22-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for AT 101

The citations listed below are publications that use Tocris products. Selected citations for AT 101 include:

1 Citation: Showing 1 - 1

  1. Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells.
    Authors: Chen Et al.
    World J Gastroenterol  2016;11:e0156145

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