Chemical Name: 1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde
Biological ActivityGossypol is a lipophilic agent derived from cottonseed. Exhibits multiple biological effects including antifertility and anticancer activity. Proapoptotic; downregulates Bcl-2 and Bcl-XL.
R-enantiomer also available.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Gossypol: a contraceptive for men.
Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells.
Zhang et al.
Gosspyol: prototype of inhibitors targeted to dinucleotide folds.
Vander Jagt et al.
Citations for Gossypol
The citations listed below are publications that use Tocris products. Selected citations for Gossypol include:
3 Citations: Showing 1 - 3
Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101).
Authors: Mani Et al.
PLoS One 2015;15:224
Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells.
Authors: Hsiao Et al.
Mol Vis 2012;18:2033
(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.
Authors: Pang Et al.
Mol Cancer Ther 2011;10:795
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