Chemical Name: 1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde
Biological ActivityLipophilic agent derived from cottonseed. Exhibits multiple biological effects including antifertility and anticancer activity. Proapoptotic; downregulates Bcl-2 and Bcl-XL.
R-enantiomer also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Gossypol: a contraceptive for men.
Gosspyol: prototype of inhibitors targeted to dinucleotide folds.
Vander Jagt et al.
Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells.
Zhang et al.
Citations for Gossypol
The citations listed below are publications that use Tocris products. Selected citations for Gossypol include:
3 Citations: Showing 1 - 3
Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101).
Authors: Mani Et al.
PLoS One 2015;15:224
Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells.
Authors: Hsiao Et al.
Mol Vis 2012;18:2033
(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.
Authors: Pang Et al.
Mol Cancer Ther 2011;10:795
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