Gossypol (CAS 303-45-7): R&D Systems
Catalog Number: 1964
Chemical Name: 1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde
Biological Activity
Lipophilic agent derived from cottonseed. Exhibits multiple biological effects including antifertility and anticancer activity. Proapoptotic; downregulates Bcl-2 and Bcl-XL. R-enantiomer available (Cat. No. 3367).
Technical Data
  • M.Wt:
    518.56
  • Formula:
    C30H30O8
  • Solubility:
    Soluble to 25 mM in ethanol with gentle warming and to 25 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    303-45-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Gossypol: a contraceptive for men.
    Coutinh
    Contraception, 2002;65:259
  2. Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells.
    Zhang et al.
    Biochem.Pharmacol., 2003;66:93
  3. Gosspyol: prototype of inhibitors targeted to dinucleotide folds.
    Vander Jagt et al.
    Curr.Med.Chem., 2000;7:479
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Gossypol include:

2 Citations: Showing 1 - 2
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  1. Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101).
    Authors: Mani Et al.
    PLoS One 2015;15:224
  2. Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells.
    Authors: Hsiao Et al.
    Mol Vis 2012;18:2033

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