Atipamezole hydrochloride

Tocris Bioscience | Catalog # 2937

Selective α2 antagonist
Tocris Bioscience

Key Product Details

Description

Selective α2 antagonist
View all Adrenergic alpha-2 Receptor Antagonists »

Product Description

Atipamezole hydrochloride is a selective α2-adrenergic receptor antagonist (Ki values are 1.1, 1.0, 0.89, 1300 and 6500 nM for α2A, α2B, α2C, α1A and α1B receptors respectively). Brain penetrant.

Product Specifications for Atipamezole hydrochloride

Molecular Weight

248.75

Formula

C14H16N2.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

5-(2-Ethyl-2,3-dihydro-1H-indene-2-yl)-1H-imidazole hydrochloride

CAS Number

104075-48-1

PubChem ID

13649426

InChI Key

PCCVCJAQMHDWJY-UHFFFAOYSA-N

SMILES

CCC2(C3=CN=CN3)CC1=CC=CC=C1C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 24.87 100
DMSO 24.87 100

Preparing Stock Solutions for Atipamezole hydrochloride

The following data is based on the product molecular weight 248.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.02 mL 20.10 mL 40.20 mL
5 mM 0.80 mL 4.02 mL 8.04 mL
10 mM 0.40 mL 2.01 mL 4.02 mL
50 mM 0.08 mL 0.40 mL 0.80 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for Atipamezole hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Atipamezole hydrochloride

For research use only

Citations for Atipamezole hydrochloride

Customer Reviews for Atipamezole hydrochloride (1)

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  • behavioral pharmacology in rats
    Name: Corinne Kiessling
    Species: Rat
    Assay Type: In Vivo
    Verified Customer | Posted 01/04/2018
    This comes out of solution easily, even with sonicating. After fully dissolving in DMSO, add water slowly and continue to vortex or sonicate.
    Behavioral neuropharmacology. Atimpamezole (0.1-1.0 mg/mL) was dissolved in 50-100% DMSO and was injected systemically in rats. Atipamezole is highly selective for the alpha2- noradrenergic receptor, and was used as a reference compound during behaviral testing.

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