Chemical Name: 5-(2-Ethyl-2,3-dihydro-1H-indene-2-yl)-1H-imidazole hydrochloride
Biological ActivityAtipamezole hydrochloride is a selective α2-adrenergic receptor antagonist (Ki values are 1.1, 1.0, 0.89, 1300 and 6500 nM for α2A, α2B, α2C, α1A and α1B receptors respectively). Brain penetrant.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Highly selective and specific antagonism of central and peripheral alpha 2-adrenoceptors by atipamezole.
Virtanen et al.
An α2-adrenergic antagonist, atipamezole, facilitates behavioral recovery after focal cerebral ischemia in rats.
Puurunen et al.
α2A adrenergic receptor activation inhibits epileptiform activity in the rat hippocampal CA3 region.
Jurgens et al.
Citations for Atipamezole hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Atipamezole hydrochloride include:
2 Citations: Showing 1 - 2
Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors.
Authors: Harris Et al.
J Neurosci 2018;38:8922
Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury.
Authors: Hughes Et al.
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