Catalog Number: 2937
Chemical Name: 5-(2-Ethyl-2,3-dihydro-1H-indene-2-yl)-1H-imidazole hydrochloride
Biological Activity
Selective α2-adrenergic receptor antagonist (Ki values are 1.1, 1.0, 0.89, 1300 and 6500 nM for α2A, α2B, α2C, α1A and α1B receptors respectively). Brain penetrant.
Technical Data
  • M.Wt:
    248.75
  • Formula:
    C14H16N2.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    104075-48-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Highly selective and specific antagonism of central and peripheral alpha 2-adrenoceptors by atipamezole.
    Virtanen et al.
    Arch.Int.Pharmacodyn.Ther., 1989;297:190
  2. An α2-adrenergic antagonist, atipamezole, facilitates behavioral recovery after focal cerebral ischemia in rats.
    Puurunen et al.
    Neuropharmacology, 2001;40:597
  3. α2A adrenergic receptor activation inhibits epileptiform activity in the rat hippocampal CA3 region.
    Jurgens et al.
    Mol.Pharmacol., 2007;71:1572
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Atipamezole hydrochloride include:

1 Citations: Showing 1 - 1

  1. Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury.
    Authors: Hughes Et al.
    Gastroenterology 2013;154:1680

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