ATN 161

Tocris Bioscience | Catalog # 6058

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Citations (10)

Product Documents

α5β1 integrin receptor antagonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

α5β1 integrin receptor antagonist

View all Integrin Receptor Inhibitors »

Product Description

ATN 161 is a α5β1 integrin receptor antagonist. Reduces liver metastasis and improves survival in combination with 5-FU (Cat. No. 3257) in a mouse model of colon cancer. Reduces MLL tumor growth in rats and decreases tumor volume of human MDA-MB-231 cell xenografts in mice.

Product Specifications for ATN 161

Molecular Weight

597.65

Formula

C₂₃H₃₅N₉O₈S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

262438-43-7

PubChem ID

9960285

InChI Key

MMHDBUJXLOFTLC-WOYTXXSLSA-N

SMILES

CC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

Khalili A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo. Mol.Cancer Ther. 2006 PMID: 16985061
Stoeltzing Inhibition of integrin α5β1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice. Int.J.Cancer. 2003 PMID: 12584749
Livant Anti-invasive, antitumorigenic, and antimetastatic activities of the PHSCN sequence in prostate carcinoma. Cancer Res. 2000 PMID: 10667582

Product Documents for ATN 161

Certificate of Analysis

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Download SDS

Product Specific Notices for ATN 161

For research use only

Related Research Areas

Adhesion Molecules

Adhesion Molecules on Endothelial Cells

Integrins and Associated Molecules

Platelet Markers

Citations for ATN 161

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