Biological ActivityATN 161 is a α5β1 integrin receptor antagonist. Reduces liver metastasis and improves survival in combination with 5-FU (Cat. No. 3257) in a mouse model of colon cancer. Reduces MLL tumor growth in rats and decreases tumor volume of human MDA-MB-231 cell xenografts in mice.
(Modifications: Pro-1 = N-terminal Ac, Asn-5 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Anti-invasive, antitumorigenic, and antimetastatic activities of the PHSCN sequence in prostate carcinoma.
Livant et al.
Cancer Res., 2000;60:309
A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo.
Khalili et al.
Mol.Cancer Ther., 2006;5:2271
Inhibition of integrin α5β1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice.
Stoeltzing et al.
Citation for ATN 161
The citations listed below are publications that use Tocris products. Selected citations for ATN 161 include:
1 Citation: Showing 1 - 1
Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation.
Authors: Albarrán-Juárez Et al.
J Exp Med 2018;215:2655
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