Biological ActivityAtosiban is a potent oxytocin receptor (OTR) antagonist. Inhibits oxytocin-induced increase in Ca2+ concentration in myometrial cells in vitro (IC50 = 5 nM) Activates NF-κB and MAPK pathways in human amnion via Gαi signaling, resulting in pro-inflammatory effects. Inhibits oxytocin-induced uterine contractions in vivo and in vitro. Effective in a rat preterm labor model.
(Modifications: X-1 = Mpr, Tyr-2 = D-Tyr(OEt), X-8 = Orn, Gly-9 = C-terminal amide, Cyclized: X-1 - Cys-6)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The oxyt. receptor antagonist, Atosiban, activates pro-inflammatory pathways in human amnion via Gαi signalling.
Kim et al.
Differential effects of oxyt. receptor antagonists, Atosiban and Nolasiban, on oxyt. receptor-mediated signaling in human amnion and myometrium.
Kim et al.
Evaluation of 1-deamino-[D-Tyr(Oethyl)2, Thr4, Orn8] vasotocin, an oxyt. antagonist, in animal models of uterine contractility and preterm labor: a new tocolytic agent.
Hahn et al.
Antagonists for the human oxyt. receptor: an in vitro study.
Maggi et al.
Citation for Atosiban
The citations listed below are publications that use Tocris products. Selected citations for Atosiban include:
1 Citation: Showing 1 - 1
Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation
Authors: Li Et al.
Cell Rep 2021;36:109411
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