ATPA

  ( 7 citations )    
Product Datasheet
Catalog Number:1107
Chemical Name:(RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid
Product Details
Citations (7)
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Reviews
Biological Activity
A selective and potent GluR5 kainate receptor agonist (Ki = 4.3 nM), inactive at GluR6 (Ki > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (Ki values of 6 - 14 μM). Also available as part of the Kainate Receptor Tocriset™.
Technical Data
  • M.Wt:
    228.25
  • Formula:
    C10H16N2O4
  • Solubility:
    Soluble to 10 mM in water and to 100 mM in 1eq. NaOH
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    140158-50-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for ATPA include:

7 Citations: Showing 1 - 7
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  1. Kynurenic Acid Induces Impairment of Oligodendrocyte Viability: On the Role of Glutamatergic Mechanisms.
    Authors: Langner Et al.
    Neurochem Res  2017;42:838
  2. Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice.
    Authors: Song Et al.
    Front Pediatr  2015;11:25
  3. Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro.
    Authors: Randall Et al.
    Eur J Neurosci  2011;33:914
  4. Glutamatergic mechanisms for speed control and network operation in the rodent locomotor CpG.
    Authors: Talpalar and Kiehn
    Front Neural Circuits  2010;4
  5. ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function.
    Authors: Dargan Et al.
    Neuropharmacology  2009;56:121
  6. Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa.
    Authors: Xu Et al.
    Mol Pain  2006;2:29
  7. Astrocyte-mediated activation of neuronal kainate receptors.
    Authors: Liu Et al.
    Mol Pain  2004;101:3172

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