ATPA

Key Product Details

Product Description

ATPA is a selective and potent GluK1 (formerly GluR5) kainate receptor agonist (K_i = 4.3 nM), inactive at GluK6 (formerly GluR6) (K_i > 1 mM) and only weakly active at AMPA receptors (GluA1-4) and the kainate receptors GluK5 (formerly KA-2) and GluK3 (formerly GluR7) (K_i values of 6 - 14 μM).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Product Specifications for ATPA

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ATPA

The following data is based on the product molecular weight 228.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

7 6 5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	21.91 mL	109.53 mL	219.06 mL
1 mM	4.38 mL	21.91 mL	43.81 mL
2 mM	2.19 mL	10.95 mL	21.91 mL
10 mM	0.44 mL	2.19 mL	4.38 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 43 publications citing the usage of this product.

• Matzen AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazole bioisasteres of glutamic acid. J.Med.Chem. 1997 PMID: 9046343
• Moldrich Excitotoxic injury profiles of low-affinity kainate receptor agonists in neuronal cultures. Eur.J.Pharmacol. 1999 PMID: 10478637
• Clarke A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature 1997 PMID: 9335499

Product Documents for ATPA