Catalog Number: 1107
Chemical Name: (RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid
Biological Activity
A selective and potent GluR5 kainate receptor agonist (Ki = 4.3 nM), inactive at GluR6 (Ki > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (Ki values of 6 - 14 μM). Also available as part of the Kainate Receptor Tocriset™.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in water and to 100 mM in 1eq. NaOH
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission.
    Clarke et al.
    Nature, 1997;389:599
  2. AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazole bioisasteres of glutamic acid.
    Matzen et al.
    J.Med.Chem., 1997;40:520
  3. Excitotoxic injury profiles of low-affinity kainate receptor agonists in neuronal cultures.
    Moldrich et al.
    Eur.J.Pharmacol., 1999;378:R1
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