Catalog Number: 1107
Chemical Name: (RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid
Biological Activity
A selective and potent GluR5 kainate receptor agonist (Ki = 4.3 nM), inactive at GluR6 (Ki > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (Ki values of 6 - 14 μM). Also available as part of the Kainate Receptor Tocriset™.
Technical Data
  • M.Wt:
    228.25
  • Formula:
    C10H16N2O4
  • Solubility:
    Soluble to 10 mM in water and to 100 mM in 1eq. NaOH
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    140158-50-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission.
    Clarke et al.
    Nature, 1997;389:599
  2. AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazole bioisasteres of glutamic acid.
    Matzen et al.
    J.Med.Chem., 1997;40:520
  3. Excitotoxic injury profiles of low-affinity kainate receptor agonists in neuronal cultures.
    Moldrich et al.
    Eur.J.Pharmacol., 1999;378:R1
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ATPA include:

5 Citations: Showing 1 - 5
Filter your results:

  1. Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice.
    Authors: Song Et al.
    Front Pediatr 2015;11:25
  2. Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro.
    Authors: Randall Et al.
    Eur J Neurosci 2011;33:914
  3. ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function.
    Authors: Dargan Et al.
    Neuropharmacology 2009;56:121
  4. Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa.
    Authors: Xu Et al.
    Mol Pain 2006;2:29
  5. Astrocyte-mediated activation of neuronal kainate receptors.
    Authors: Liu Et al.
    Mol Pain 2004;101:3172

Have you used ATPA?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information