Axitinib

Catalog # Availability Size / Price Qty
4350/10
4350/50
VEGF Receptor Inhibitors Small Molecule
1 Image
Description: Potent VEGFR-1, -2 and -3 inhibitor

Chemical Name: N-Methyl-[[3[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-benzamide

Purity: ≥99%

Product Details
Citations (3)
Supplemental Products
Reviews

Biological Activity

Potent inhibitor of VEGFR-2, -3, and -1 (IC50 values are 0.2, 0.1-0.3, and 1.2 nM respectively). Exhibits minimal activity against a panel of ~100 protein kinase. Inhibits angiogenesis and vascular permeability. Also a high affinity BCR-ABL1 (T315I) inhibitor (Ki = 149 pM for autophosphorylated ABL1 (T315I)). Blocks proliferation of Ba/F3 cells expressing BCR-ABL1 (T315I). Orally available.

Technical Data

M.Wt:
386.47
Formula:
C22H18N4OS
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
319460-85-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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Citations for Axitinib

The citations listed below are publications that use Tocris products. Selected citations for Axitinib include:

3 Citations: Showing 1 - 3

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