Axl Antibody - Humanized, (Research Grade tilvestamab Biosimilar) - Low Endotoxin, Azide and BSA Free

Novus Biologicals | Catalog # NBP3-28445

Recombinant Monoclonal Antibody
Novus Biologicals

Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Functional

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 expressed in CHO

Format

Low Endotoxin, Azide and BSA Free
View all Axl Primary Antibodies »

Product Specifications

Immunogen

AXL / UFO

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Description

The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 146.16 kDa.

Also known as 'tilvestamab'.

This product is shipped at ambient temperature. Upon receipt, store immediately at -20C or lower for 12 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.

Endotoxin Level

< 0.001EU/ug,determined by LAL method.

Scientific Data Images

Axl Antibody (tilvestamab) - Humanized

Functional: Axl Antibody (tilvestamab) - Humanized[NBP3-28445] -

The endocytosis ratio tilvestamab by U251 increased with the increase of antibody concentration, and the Internalization Rate (%) reached 40% at antibody concentration of 1 nM.
Axl Antibody (tilvestamab) - Humanized

Functional: Axl Antibody (tilvestamab) - Humanized[NBP3-28445] -

Axl Antibody (tilvestamab) - Humanized P-AKT Test was evaluated using U251 cell. The max induction fold was approximately 1.43.
Axl Antibody (tilvestamab) - Humanized

ELISA: Axl Antibody (tilvestamab) - Humanized[NBP3-28445] -

Immobilized human Axl FC at 2 ug/mL can bind Axl Antibody (tilvestamab) - Humanized, EC50=0.01542 ug/mL.
Axl Antibody (tilvestamab) - Humanized

Flow Cytometry: Axl Antibody (tilvestamab) - Humanized[NBP3-28445] -

Human AXL HEK293 cells were stained with Axl Antibody (tilvestamab) - Humanized and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC50=0.07318 ug/mL.
Axl Antibody - Humanized, (Research Grade tilvestamab Biosimilar) - Low Endotoxin, Azide and BSA Free

Flow Cytometry: CHO Axl mAb (tilvestamab) - Humanized [NBP3-28445]

Flow Cytometry: CHO Axl mAb (tilvestamab) - Humanized [NBP3-28445] - Axl expression on human monocyte-derived macrophages. The macrophages were treated with Tilvestamab PE antibody (blue), diluted 1:100, or human IgG1 PE isotype control antibody (red) for 30 minutes on ice. Image from a verified customer review. The customer used the PE-conjugated version of NBP3-28445, which is listed under NBP3-28445PE.

Applications

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Functional

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry Panel Builder

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Advanced Features

  • Spectra Viewer - Custom analysis of spectra from multiple fluorochromes
  • Spillover Popups - Visualize the spectra of individual fluorochromes
  • Antigen Density Selector - Match fluorochrome brightness with antigen density
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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Formulation

Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)

Format

Low Endotoxin, Azide and BSA Free

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C in powder form. Store at -80C once reconstituted.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Axl

Axl is encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.

Long Name

Axl Receptor Tyrosine Kinase

Alternate Names

AI323647, ARK, JTK11, Tyro7, UFO

Gene Symbol

AXL

UniProt

P30530 (Human)

Additional Axl Products

Product Documents

Certificate of Analysis

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Product Specific Notices

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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