Potent and selective human P2X7
values are 5 - 7 and > 10,000 nM at hP2X7
respectively) that is completely without effect at all other P2X subtypes. Inhibits BzATP-mediated calcium influx and inhibits ATP-mediated IL-1β
release in vitro
values are 15 and 92 nM respectively).
Soluble to 10 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from AstraZeneca
Characterization of a selective and potent antagonist of human P2X7 receptors, AZ11645373.
Stokes et al.
Mechanism of action of species-selective P2X(7) receptor antagonists.
Michel et al.
Novel P2X7 receptor antagonists.
Alcaraz et al.
The citations listed below are publications that use Tocris products. Selected citations for AZ 11645373 include:
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