AZ 11645373

Catalog # Availability Size / Price Qty
3317/10
3317/50
AZ 11645373 | CAS No. 227088-94-0 | P2X Receptor Antagonists
1 Image
Description: Potent and selective human P2X7 antagonist

Chemical Name: 3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione

Purity: ≥98%

Product Details
Citations (7)
Supplemental Products
Reviews

Biological Activity

Potent and selective human P2X7 antagonist (KB values are 5 - 7 and > 10,000 nM at hP2X7 and rP2X7 respectively) that is completely without effect at all other P2X subtypes. Inhibits BzATP-mediated calcium influx and inhibits ATP-mediated IL-1β release in vitro (KB values are 15 and 92 nM respectively).

Technical Data

M.Wt:
463.51
Formula:
C24H21N3O5S
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
227088-94-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from AstraZeneca

Background References

  1. Characterization of a selective and potent antagonist of human P2X7 receptors, AZ11645373.
    Stokes et al.
    Br.J.Pharmacol., 2006;149:880
  2. Mechanism of action of species-selective P2X(7) receptor antagonists.
    Michel et al.
    Br.J.Pharmacol., 2009;156:1312
  3. Novel P2X7 receptor antagonists.
    Alcaraz et al.
    Bioorg.Med.Chem.Letts., 2003;13:4043

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for AZ 11645373

The citations listed below are publications that use Tocris products. Selected citations for AZ 11645373 include:

7 Citations: Showing 1 - 7

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for AZ 11645373

There are currently no reviews for this product. Be the first to review AZ 11645373 and earn rewards!

Have you used AZ 11645373?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.