Chemical Name: 3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione
Biological ActivityPotent and selective human P2X7 antagonist (KB values are 5 - 7 and > 10,000 nM at hP2X7 and rP2X7 respectively) that is completely without effect at all other P2X subtypes. Inhibits BzATP-mediated calcium influx and inhibits ATP-mediated IL-1β release in vitro (KB values are 15 and 92 nM respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterization of a selective and potent antagonist of human P2X7 receptors, AZ11645373.
Stokes et al.
Mechanism of action of species-selective P2X(7) receptor antagonists.
Michel et al.
Novel P2X7 receptor antagonists.
Alcaraz et al.
Citations for AZ 11645373
The citations listed below are publications that use Tocris products. Selected citations for AZ 11645373 include:
7 Citations: Showing 1 - 7
P2X7Rs are involved in cell death, growth and cellular signaling in primary human osteoblasts
Authors: Agrawal Et al.
Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP.
Authors: Karmakar Et al.
Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors.
Authors: Kawano Et al.
PLoS One 2015;10:e0127919
The ATP Receptors P2X7 and P2X4 Modulate High Glucose and Palmitate-Induced Inflammatory Responses in Endothelial Cells.
Authors: Sathanoori Et al.
PLoS One 2015;10:e0125111
An Improved Method for P2X7R Antagonist Screening.
Authors: Soares-Bezerra Et al.
Arthritis Rheumatol 2015;10:e0123089
Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism.
Authors: Bhaskaracharya Et al.
PLoS One 2014;9:e93058
Mitochondrial superoxide generation enhances P2X7R-mediated loss of cell surface CD62L on naive human CD4+ T lymphocytes.
Authors: Foster Et al.
J Immunol 2013;190:1551
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