AZ 11645373

Tocris Bioscience | Catalog # 3317

Potent and selective human P2X7 antagonist
Tocris Bioscience

Key Product Details

Description

Potent and selective human P2X7 antagonist
View all P2X Receptor Antagonists »

Product Description

AZ 11645373 is a potent and selective human P2X7 antagonist (KB values are 5 - 7 and > 10,000 nM at hP2X7 and rP2X7 respectively) that is completely without effect at all other P2X subtypes. Inhibits BzATP-mediated calcium influx and inhibits ATP-mediated IL-1β release in vitro (KB values are 15 and 92 nM respectively).

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Product Specifications for AZ 11645373

Molecular Weight

463.51

Formula

C24H21N3O5S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione

CAS Number

227088-94-0

PubChem ID

9804433

InChI Key

VQEHBLGYANQWEA-UHFFFAOYSA-N

SMILES

O=C(CSC4=O)N4C(COC2=CC=C(C3=CC=CC([N+]([O-])=O)=C3)C=C2)CCC1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.64 10

Preparing Stock Solutions for AZ 11645373

The following data is based on the product molecular weight 463.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.57 mL 107.87 mL 215.75 mL
0.5 mM 4.31 mL 21.57 mL 43.15 mL
1 mM 2.16 mL 10.79 mL 21.57 mL
5 mM 0.43 mL 2.16 mL 4.31 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 30 publications citing the usage of this product.

Product Documents for AZ 11645373

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AZ 11645373

For research use only

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