AZ 11645373

Catalog # Availability Size / Price Qty
AZ 11645373 | CAS No. 227088-94-0 | P2X Receptor Antagonists
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Description: Potent and selective human P2X7 antagonist

Chemical Name: 3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione

Purity: ≥98%

Product Details
Citations (7)
Supplemental Products

Biological Activity

AZ 11645373 is a potent and selective human P2X7 antagonist (KB values are 5 - 7 and > 10,000 nM at hP2X7 and rP2X7 respectively) that is completely without effect at all other P2X subtypes. Inhibits BzATP-mediated calcium influx and inhibits ATP-mediated IL-1β release in vitro (KB values are 15 and 92 nM respectively).

Technical Data

Soluble to 10 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from AstraZeneca

Background References

  1. Characterization of a selective and potent antagonist of human P2X7 receptors, AZ11645373.
    Stokes et al.
    Br.J.Pharmacol., 2006;149:880
  2. Mechanism of action of species-selective P2X(7) receptor antagonists.
    Michel et al.
    Br.J.Pharmacol., 2009;156:1312
  3. Novel P2X7 receptor antagonists.
    Alcaraz et al.
    Bioorg.Med.Chem.Letts., 2003;13:4043

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Citations for AZ 11645373

The citations listed below are publications that use Tocris products. Selected citations for AZ 11645373 include:

7 Citations: Showing 1 - 7


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