AZ 13705339

Catalog # Availability Size / Price Qty
AZ 13705339 | CAS No. 2016806-57-6 | PAK Inhibitors
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Description: Highly potent PAK1 and PAK2 inhibitor

Chemical Name: 2-[[[2-[[3-(Ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylphenyl]amino]methyl]benzonitrile

Product Details

Biological Activity

Highly potent PAK1 and PAK2 inhibitor (IC50 values are 0.33 and 6 nM for PAK1 and PAK2, respectively). Displays >7500-fold selectivity for PAK1 over PAK4 (IC50 = 2.6 μM).

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol with gentle warming
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Optimization of highly kinase selective bis-anilino pyrimidine PAK1 inhibitors.
    McCoull et al.
    ACS Med.Chem.Lett., 2016;7:1118

Product Datasheets

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