AZ 13705339

Tocris Bioscience | Catalog # 6177

Highly potent PAK1 and PAK2 inhibitor
Tocris Bioscience

Key Product Details

Description

Highly potent PAK1 and PAK2 inhibitor
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Product Description

AZ 13705339 is a highly potent PAK1 and PAK2 inhibitor (IC50 values are 0.33 and 6 nM for PAK1 and PAK2, respectively). Displays >7500-fold selectivity for PAK1 over PAK4 (IC50 = 2.6 μM).

Product Specifications for AZ 13705339

Molecular Weight

629.75

Formula

C33H36FN7O3S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-[[[2-[[3-(Ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylphenyl]amino]methyl]benzonitrile

CAS Number

2016806-57-6

PubChem ID

129909860

InChI Key

WPFLVPJXKWCRQK-UHFFFAOYSA-N

SMILES

CCS(=O)(C1=C(N2CCN(CC2)C)C=CC(NC3=NC=C(C(N(C4=CC(CO)=CC=C4C)CC5=C(C#N)C=CC=C5)=N3)F)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 62.98 100
Ethanol 12.6 20 with gentle warming

Preparing Stock Solutions for AZ 13705339

The following data is based on the product molecular weight 629.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.59 mL 7.94 mL 15.88 mL
5 mM 0.32 mL 1.59 mL 3.18 mL
10 mM 0.16 mL 0.79 mL 1.59 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Product Documents for AZ 13705339

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AZ 13705339

For research use only

Related Research Areas

Intracellular Kinases

Customer Reviews for AZ 13705339 (1)

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  • Product works well for PAK2 inhibition
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Human brain microvascular endothelial cells
    Verified Customer | Posted 11/13/2020
    10 nM of the compound inhibits the expression of PAK2 protein, assessed by western blotting.
    AZ 13705339 6177

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