AZ 13705339

Catalog # Availability Size / Price Qty
6177/10
6177/50
Cat.No. 6177 - AZ 13705339 | C33H36FN7O3S | CAS No. 2016806-57-6
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Description: Highly potent PAK1 and PAK2 inhibitor

Chemical Name: 2-[[[2-[[3-(Ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylphenyl]amino]methyl]benzonitrile

Purity: ≥98%

Product Details
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Biological Activity

Highly potent PAK1 and PAK2 inhibitor (IC50 values are 0.33 and 6 nM for PAK1 and PAK2, respectively). Displays >7500-fold selectivity for PAK1 over PAK4 (IC50 = 2.6 μM).

Technical Data

M.Wt:
629.75
Formula:
C33H36FN7O3S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2016806-57-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Optimization of highly kinase selective bis-anilino pyrimidine PAK1 inhibitors.
    McCoull et al.
    ACS Med.Chem.Lett., 2016;7:1118

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