AZ 6102

   
Product Datasheet
Catalog Number:5775
Chemical Name:rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidin-4-one
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Biological Activity
Potent TNKS2 and TNKS1 inhibitor (IC 50 values are 1 and 3 nM, respectively). Exhibits >100-fold selectivity for TNKS1/2 over PARP-1, PARP-2 and PARP-6. Inhibits Wnt signaling in DLD-1 cells (IC 50 = 5 nM). Exhibits moderate oral bioavailability.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of AZ6102 is reviewed on the chemical probes website.
Technical Data
  • M.Wt:
    428.53
  • Formula:
    C25H28N6O
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    1645286-75-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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