AZ Dyrk1B 33

Catalog # Availability Size / Price Qty
AZ Dyrk1B 33 | CAS No. 1679330-37-0 | DYRK Inhibitors
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Description: Potent and selective Dyrk1B kinase inhibitor

Chemical Name: 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine

Purity: ≥98%

Product Details

Biological Activity

AZ Dyrk1B 33 is a potent and selective ATP-competitive Dyrk1B kinase inhibitor (IC50 = 7 nM); displays distinct cellular effects when compared to DYRK1B knockdown through siRNA. Demonstrates cellular in vitro activity (IC50 = 194 nM). Exhibits better selectivity than AZ 191 (Cat. No 5232); displays no off-target effects against a panel of 124 kinases tested (no kinase was inhibited above 50% at 1 μM).

Technical Data

Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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