Catalog Number: 6085
Chemical Name: Ethyl 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-3-pyridinecarboxylate
Biological Activity
High affinity P2Y12 antagonist (Kd = 11 nM). Causes a dose-dependent increase in blood flow and inhibits ADP-induced platelet aggregation in vivo. Antithrombotic.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283.
    Bach et al.
    J.Med.Chem., 2013;56:7015
  2. Agonist-bound structure of the human P2Y12 receptor.
    Zhang et al.
    Nature, 2014;509:119
  3. Structure of the human P2Y12 receptor in complex with an antithrombotic drug.
    Zhang et al.
    Nature, 2014;509:115
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