Home / mTOR Inhibitors / AZD 3147

AZD 3147

Catalog #: 5615 Datasheet / COA / SDS

Discontinued Product

5615 has been discontinued.
View all mTOR Inhibitors products.
AZD 3147 | CAS No. 1101810-02-9 | mTOR Inhibitors
1 Image
Description: Potent and selective dual mTORC1 and 2 inhibitor; orally bioavailable

Chemical Name: N-[4-[4-[1-(Cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methyl-4-morpholinyl]-2-pyrimidinyl]phenyl]-N'-(2-hydroxyethyl)thiourea

Purity: ≥95%

Product Details
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AZD 3147 is a potent and selective dual mTORC1 and 2 inhibitor (IC50 = 1.5 nM). Exhibits >300-fold selectivity for mTOR over PI 3-kinase isoforms. Orally bioavailable.

Technical Data

M.Wt:
517.66
Formula:
C24H31N5O4S2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
1101810-02-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2.
    Pike et al.
    J.Med.Chem., 2015;58:2326

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for AZD 3147

There are currently no reviews for this product. Be the first to review AZD 3147 and earn rewards!

Have you used AZD 3147?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.