Chemical Name: trans-4-[-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid
Biological ActivityAZD 3988 is a potent and selective diacylglycerol acyltransferase (DGAT-1) inhibitor (IC50 = 0.6 nM). Exhibits selectivity for DGAT-1 over DGAT-2, Kv11.1 (hERG) and cytochrome P450 enzymes. Suppresses triacylglyceride (TAG) plasma excursion and adipose tissue TAG synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable.
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Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes.
McCoull et al.
Citation for AZD 3988
The citations listed below are publications that use Tocris products. Selected citations for AZD 3988 include:
1 Citation: Showing 1 - 1
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition.
Authors: Mahoney Et al.
Nat Commun 2019;10:96
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