AZD 3988

Key Product Details

Product Description

AZD 3988 is a potent and selective diacylglycerol acyltransferase (DGAT-1) inhibitor (IC₅₀ = 0.6 nM). Exhibits selectivity for DGAT-1 over DGAT-2, K_v11.1 (hERG) and cytochrome P450 enzymes. Suppresses triacylglyceride (TAG) plasma excursion and adipose tissue TAG synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Product Specifications for AZD 3988

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AZD 3988

The following data is based on the product molecular weight 456.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.19 mL	10.95 mL	21.91 mL
5 mM	0.44 mL	2.19 mL	4.38 mL
10 mM	0.22 mL	1.10 mL	2.19 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

• McCoull Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg.Med.Chem.Lett. 2012 PMID: 22608962

Product Documents for AZD 3988