Catalog Number: 4837
Chemical Name: trans-4-[-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid
Biological Activity
Potent and selective diacylglycerol acyltransferase (DGAT-1) inhibitor (IC50 = 0.6 nM). Exhibits selectivity for DGAT-1 over DGAT-2, Kv11.1 (hERG) and cytochrome P450 enzymes. Suppresses triacylglyceride (TAG) plasma excursion and adipose tissue TAG synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable.
Technical Data
  • M.Wt:
    456.44
  • Formula:
    C23H22F2N4O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in 1eq. NaOH with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    892489-52-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Background References
  1. Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes.
    McCoull et al.
    Bioorg.Med.Chem.Lett., 2012;22:3873

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