AZD 6482

   
Product Datasheet
Catalog Number:4839
Chemical Name:(-)-2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid
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Biological Activity
Potent and selective inhibitor of PI 3-kinase β (PI 3-Kβ) (IC50 values are 0.69, 13.6, 47.8 and 136 nM for PI 3-Kβ, PI 3-Kδ, PI 3-Kγ and PI 3-Kα, respectively). Selectively inhibits in vivo growth of the PTEN-deficient tumor xenografts HCC70 and PC3. Also exhibits antithrombotic activity.
Technical Data
  • M.Wt:
    408.45
  • Formula:
    C22H24N4O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in 1eq. HCl
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    1173900-33-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
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