AZD 6482

Key Product Details

Product Description

AZD 6482 is a potent and selective inhibitor of PI 3-kinase β (PI 3-Kβ) (IC₅₀ values are 0.69, 13.6, 47.8 and 136 nM for PI 3-Kβ, PI 3-Kδ, PI 3-Kγ and PI 3-Kα, respectively). Selectively inhibits in vivo growth of the PTEN-deficient tumor xenografts HCC70 and PC3. Also exhibits antithrombotic activity.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Product Specifications for AZD 6482

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AZD 6482

The following data is based on the product molecular weight 408.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.45 mL	12.24 mL	24.48 mL
5 mM	0.49 mL	2.45 mL	4.90 mL
10 mM	0.24 mL	1.22 mL	2.45 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Ni Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. Cancer Discov. 2012 PMID: 22588880
• Nylander Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and Ins sensitivity, using AZD6482 a novel PI3Kβ inhibitor. J.Thromb.Haemost. 2012 PMID: 22906130

Product Documents for AZD 6482