AZD 6482

Catalog # Availability Size / Price Qty
4839/10
4839/50
Cat.No. 4839 - AZD 6482 | C22H24N4O4 | CAS No. 1173900-33-8
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Description: Potent and selective PI 3-Kβ inhibitor

Chemical Name: (-)-2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid

Purity: ≥98%

Product Details
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Biological Activity

Potent and selective inhibitor of PI 3-kinase β (PI 3-Kβ) (IC50 values are 0.69, 13.6, 47.8 and 136 nM for PI 3-Kβ, PI 3-Kδ, PI 3-Kγ and PI 3-Kα, respectively). Selectively inhibits in vivo growth of the PTEN-deficient tumor xenografts HCC70 and PC3. Also exhibits antithrombotic activity.

Technical Data

M.Wt:
408.45
Formula:
C22H24N4O4
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in 1eq. HCl
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1173900-33-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.

Product Datasheets

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