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AZD 9291

Catalog #: 8873 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8873/10
8873/50

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AZD 9291 | CAS No. 1421373-65-0 | EGF Receptor Inhibitors
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Description: Potent mutant-selective EGFR inhibitor

Chemical Name: N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide

Purity: ≥98%

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Biological Activity

AZD 9291 is a potent mutant-selective EGFR inhibitor (IC50 values are 1 and 12 nM against EGFR mutants L858R/T790M and L858R, respectively). AZD 9291 exhibited nearly 200 times greater potency against L858R/T790M than wild-type EGFR. In vivo, AZD 9291 causes tumor regression in mutant EGFR xenograft models of non-small cell lung cancer (NSCLC) and transgenic mutant T790M EGFR disease models. AZD 9291 is orally bioavailable.

Technical Data

M.Wt:
499.61
Formula:
C28H33N7O2
Solubility:
Soluble to 50 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1421373-65-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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