Azimilide dihydrochloride

Catalog # Availability Size / Price Qty
6318/50
6318/10
Azimilide dihydrochloride | CAS No. 149888-94-8 | Voltage-gated Potassium Channel Blockers
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Description: Kv11.1 (hERG) channel blocker

Chemical Name: 1-[[[5-(4-Chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione dihydrochloride

Purity: ≥97%

Product Details
Reviews (1)

Biological Activity

Azimilide dihydrochloride is a Kv11.1 (hERG) channel blocker, blocks rapidly activating and slowly activating components of delayed rectifier K+ currents (IC50 of 0.4 mM and 3 mM, respectively). Also inhibits Na+/Ca2+ exchanger in vitro. Shows inhibition of Na+ currents, L-type Ca2+ currents and other K+ currents at high concentrations.

Technical Data

M.Wt:
530.88
Formula:
C23H28ClN5O3.2HCl
Solubility:
Soluble to 1 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
149888-94-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Azimilide was used to study Kv 11.1 channel gating mechanism
By Anonymous on 11/07/2018
Application: Species: Human

Azimilide was used to study Kv11.1 channel blocking properties. Kv11.1 channels were being studied to understand the voltage gating mechanism and how the activation and blocking of the channel is different than other Kv channels.


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