Chemical Name: 1-[[[5-(4-Chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione dihydrochloride
Biological ActivityAzimilide dihydrochloride is a Kv11.1 (hERG) channel blocker, blocks rapidly activating and slowly activating components of delayed rectifier K+ currents (IC50 of 0.4 mM and 3 mM, respectively). Also inhibits Na+/Ca2+ exchanger in vitro. Shows inhibition of Na+ currents, L-type Ca2+ currents and other K+ currents at high concentrations.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibitory Effect of Azimilide on Na+/Ca2+ Exchange Current in Guinae-Pig Cardiac Myocytes.
Watanabe and Kimura
Blockade of HERG channels by the class III antiarrhythmic Azimilide: mode of action.
Busch et al.
Blockade of Human IsK channels expression in Xenopus oocytes by the novel class III antiarrhythmic NE-10064.
Busch et al.
Use-dependent effects of the class III antiarrhythmic agent NE-10064 (azimilide) on cardiac repolarisation: block of delayed rectifier potassium and L-type calcium currents.
Fermini et al.
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Azimilide was used to study Kv11.1 channel blocking properties. Kv11.1 channels were being studied to understand the voltage gating mechanism and how the activation and blocking of the channel is different than other Kv channels.