B7-H6 is a transmembrane immune regulatory protein that binds to NKp30 expressed on NK cells. Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis. B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells. The expression of NKp30 ligands on tumor cells correlates with tumor cell sensitivity to NKp30-dependent cell lysis.
B7-H6 Antibody (1018457) [DyLight 405]
Novus Biologicals | Catalog # FAB71444E
Key Product Details
Species Reactivity
Human
Applications
Blockade of Receptor-ligand Interaction
Label
DyLight 405 (Excitation = 400 nm, Emission = 420 nm)
Antibody Source
Monoclonal Mouse IgG2B Clone # 1018457
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Product Specifications
Immunogen
Human embryonic kidney cell HEK293-derived human B7-H6
Asp25-Ser262
Accession # Q68D85
Asp25-Ser262
Accession # Q68D85
Specificity
Detects human B7-H6 in direct ELISAs.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2B
Applications for B7-H6 Antibody (1018457) [DyLight 405]
Application
Recommended Usage
Blockade of Receptor-ligand Interaction
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: B7-H6
Long Name
B7 Homolog 6
Alternate Names
B7H6, DKFZp686I21167, DKFZp686O24166, NCR3LG1
Additional B7-H6 Products
Product Documents for B7-H6 Antibody (1018457) [DyLight 405]
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for B7-H6 Antibody (1018457) [DyLight 405]
DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Related Research Areas
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