BAG 956

   
Product Datasheet
Catalog Number:3606
Chemical Name:α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile
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Biological Activity
Dual PDPK1 (PDK1) and class I PI 3-K inhibitor (IC50 values are 245, 56, 446, 35 and 117 nM for PDPK1 and PI 3-K p110 -α, -β, -δ, and -γ respectively). Inhibits cellular AKT phosphorylation at Thr308. Blocks cell proliferation, causing arrest in G1 phase of the cell cycle. Slows tumor progression in mouse xenograft models.
Technical Data
  • M.Wt:
    427.5
  • Formula:
    C28H21N5
  • Solubility:
    Soluble to 40 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    853910-02-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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