BAG 956

Catalog # Availability Size / Price Qty
3606/10
3606/50
BAG 956 | CAS No. 853910-02-8 | PI 3-Kinase Inhibitors
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Description: Dual PI 3-kinase and PDPK1 (PDK1) inhibitor

Chemical Name: α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile

Purity: ≥99%

Product Details
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Biological Activity

Dual PDPK1 (PDK1) and class I PI 3-K inhibitor (IC50 values are 245, 56, 446, 35 and 117 nM for PDPK1 and PI 3-K p110 -α, -β, -δ, and -γ respectively). Inhibits cellular AKT phosphorylation at Thr308. Blocks cell proliferation, causing arrest in G1 phase of the cell cycle. Slows tumor progression in mouse xenograft models.

Technical Data

M.Wt:
427.5
Formula:
C28H21N5
Solubility:
Soluble to 40 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
853910-02-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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