Catalog Number: 4219
Alternate Names: AQ4N
Chemical Name: 1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride
Biological Activity
Bioreductive prodrug; activated by hypoxia to yield the topoisomerase II inhibitor AQ4. Displays little to no cytotoxic activity against 60 tumor cell lines tested under oxic conditions (IC50 >100 μM). Exhibits anti-tumor efficacy in vivo when combined with oxic cell cytotoxins; enhances the anti-tumor effect of cyclophosphamide (Cat. No. 4091) in a mouse tumor model.
Technical Data
  • M.Wt:
    517.4
  • Formula:
    C22H28N4O6.2HCl
  • Solubility:
    Soluble to 50 mM in water and to 25 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    252979-56-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Enhancement of the anti-tumour effect of cyclophosphamide by the bioreductive drugs AQ4N and tirapazamine.
    Friery et al.
    Br.J.Cancer, 2000;82:1469
  2. AQ4N: a new approach to hypoxia-activated cancer chemotherapy.
    Patterson and McKeown
    Br.J.Cancer, 2000;83:1589
  3. Effects of cytokine-induced macrophages on the response of tumor cells to banoxantrone (AQ4N).
    Mehibel et al.
    Mol.Cancer Ther., 2009;8:1261

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