Chemical Name: 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
Biological ActivityNitrogen mustard alkylating agent and prodrug. Phosphoramide mustard (active metabolite) forms DNA cross-links leading to cell death. Inhibits aldehyde dehydrogenase 1 (ALDH1) through its degradation product acrolein. Chemotherapeutic for the treatment of breast cancer; regulates Bax and Bcl-2 expression when administered with etoposide (Cat. No. 1226) in breast cancer cell lines.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
DNA strand breaks and DNA cross-links in peripheral mononuclear blood cells of ovarian cancer patients during chemotherapy with cyclophosphamide/carboplatin.
Hengstler et al.
Cancer Res., 1992;15:52
Inhibition of human aldehyde dehydrogenase 1 by the 4-hydroxycyclophosphamide degradation product acrolein.
Ren et al.
Drug Metab.Disp., 1999;27:133
Regulation of BAX and BCL-2 expression in breast cancer cells by chemotherapy.
Gibson et al.
Breast Cancer Research and Treatment, 1999;55:107
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