Bax channel blocker

Catalog # Availability Size / Price Qty
Bax channel blocker | CAS No. 329349-20-4 | Bcl-2 Family Inhibitors
1 Image
Description: Allosteric inhibitor of Bax channel activation
Alternative Names: BAI1

Chemical Name: 3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride

Purity: ≥98%

Product Details
Citations (2)

Biological Activity

Bax channel blocker is a allosteric inhibitor of Bax channel activation. Binds inactive Bax at allosteric site and inhibits tBID-mediated Bax activation (IC50 = 3.3 μM). Selectively inhibits Bax-dependent apoptosis. Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM).

Technical Data

Soluble to 5 mM in water and to 100 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. 3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation.
    Bombrun et al.
    J.Med.Chem., 2003;46:21
  2. Small-molecule allosteric inhibitors of BAX.
    Garner et al.
    Nat.Chem.Biol., 2019;15:322

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Bax channel blocker

The citations listed below are publications that use Tocris products. Selected citations for Bax channel blocker include:

2 Citations: Showing 1 - 2


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Bax channel blocker

There are currently no reviews for this product. Be the first to review Bax channel blocker and earn rewards!

Have you used Bax channel blocker?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.