Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50
= 0.52 μ
M). Suggested to inhibit Bax channel formation/activity.
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All Tocris products are intended for laboratory research use only.
3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation.
Bombrun et al.