Bax channel blocker
Chemical Name: 3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride
Biological ActivityAllosteric inhibitor of Bax channel activation. Binds inactive Bax at allosteric site and inhibits tBID-mediated Bax activation (IC50 = 3.3 μM). Selectively inhibits Bax-dependent apoptosis. Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM).
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation.
Bombrun et al.
Small-molecule allosteric inhibitors of BAX.
Garner et al.
Citations for Bax channel blocker
The citations listed below are publications that use Tocris products. Selected citations for Bax channel blocker include:
2 Citations: Showing 1 - 2
Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition.
Authors: Ono Et al.
PLoS One 2017;12:e0181243
Vacuolin-1 inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition.
Authors: Sano Et al.
FEBS Lett 2016;590:1576
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