Bax channel blocker

Tocris Bioscience | Catalog # 2160

Allosteric inhibitor of Bax channel activation
Tocris Bioscience

Key Product Details

Description

Allosteric inhibitor of Bax channel activation

Alternative Names

BAI1
View all Bcl-2 Family Inhibitors »

Product Description

Bax channel blocker is a allosteric inhibitor of Bax channel activation. Binds inactive Bax at allosteric site and inhibits tBID-mediated Bax activation (IC50 = 3.3 μM). Selectively inhibits Bax-dependent apoptosis. Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM).

Product Specifications for Bax channel blocker

Molecular Weight

540.12

Formula

C19H21Br2N3O.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride

CAS Number

329349-20-4

PubChem ID

2729026

InChI Key

HWFKCAFKXZFOQT-UHFFFAOYSA-N

SMILES

Cl.Cl.OC(CN1C2=C(C=C(Br)C=C2)C2=C1C=CC(Br)=C2)CN1CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.34 5
DMSO 46.72 100

Preparing Stock Solutions for Bax channel blocker

The following data is based on the product molecular weight 540.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.85 mL 9.26 mL 18.51 mL
5 mM 0.37 mL 1.85 mL 3.70 mL
10 mM 0.19 mL 0.93 mL 1.85 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

  • Garner Small-molecule allosteric inhibitors of BAX. Nat.Chem.Biol. 2019 PMID: 30718816
  • Bombrun 3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J.Med.Chem.

Product Documents for Bax channel blocker

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Bax channel blocker

For research use only

Citations for Bax channel blocker

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