Bax channel blocker

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2160/50
Bax channel blocker | CAS No. 329349-20-4 | Bcl-2 Family Inhibitors
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Description: Allosteric inhibitor of Bax channel activation
Alternative Names: BAI1

Chemical Name: 3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride

Purity: ≥98%

Product Details
Citations (2)
Reviews

Biological Activity

Allosteric inhibitor of Bax channel activation. Binds inactive Bax at allosteric site and inhibits tBID-mediated Bax activation (IC50 = 3.3 μM). Selectively inhibits Bax-dependent apoptosis. Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM).

Technical Data

M.Wt:
540.12
Formula:
C19H21Br2N3O.2HCl
Solubility:
Soluble to 5 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
329349-20-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. 3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation.
    Bombrun et al.
    J.Med.Chem., 2003;46:21
  2. Small-molecule allosteric inhibitors of BAX.
    Garner et al.
    Nat.Chem.Biol., 2019;15:322

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Citations for Bax channel blocker

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2 Citations: Showing 1 - 2

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