BAY 60-6583

Name: BAY 60-6583
Brand: Tocris Bioscience

( 6 citations )

Product Datasheet

Catalog Number:4472

Chemical Name:2-[[6-Amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]-acetamide

Product Details

Citations (6)

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Reviews

Biological Activity
Potent adenosine A_2B receptor agonist (EC₅₀ = 2.83 nM for murine A_2B receptor). Displays selectivity for A_2B over A₁, A_2Aand A₃ receptors. Decreases fMLP-induced superoxide production in neutrophils at low concentrations (1-10 nM). Cardioprotective; attenuates infarct size in a mouse model of myocardial ischemia.

Technical Data

M.Wt:

379.44
Formula:

C₁₉H₁₇N₅O₂S
Solubility:

Soluble to 100 mM in DMSO
Purity:

>98
Storage:

Store at +4°C
CAS No:

910487-58-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citations:

The citations listed below are publications that use Tocris products. Selected citations for BAY 60-6583 include:

6 Citations: Showing 1 - 6
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Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Authors: Song Nat Commun 2017;8:14108 Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome. Authors: Asano Scientific Reports 2017;7:40214 A2B adenosine receptors stimulate IL-6 production in primary murine microglia through p38 MAPKkinase pathway. Authors: Merighi Pharmacological Res 2016;117:9 Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Authors: Aherne Et al. Autophagy 2015;8:1324 Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Authors: Perez-Aso Et al. Arthritis Res Ther 2015;17:249 Blockade of A2b adenosine receptor reduces tumor growth and immune suppression mediated by myeloid-derived suppressor cells in a mouse model of melanoma. Authors: Iannone Et al. Neoplasia 2013;15:1400

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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