Catalog Number: 4472
Chemical Name: 2-[[6-Amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]-acetamide
Biological Activity
Potent adenosine A2B receptor agonist (EC50 = 2.83 nM for murine A2B receptor). Displays selectivity for A2B over A1, A2A and A3 receptors. Decreases fMLP-induced superoxide production in neutrophils at low concentrations (1-10 nM). Cardioprotective; attenuates infarct size in a mouse model of myocardial ischemia.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors.
    Eckle et al.
    Circulation, 2007;115:1581
  2. A role for the low-affinity A2B adenosine receptor in regulating superoxide generation by murine neutrophils.
    van der Hoeven et al.
    J.Pharmacol.Exp.Ther., 2011;338:1004
  3. Characterization of the A2B adenosine receptor from mouse, rabbit, and dog.
    Auchampach et al.
    J.Pharmacol.Exp.Ther., 2009;329:2
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