BAY 60-6583

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4472/10
4472/50
BAY 60-6583 | CAS No. 910487-58-0 | Adenosine A2b Receptor Agonists
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Description: Potent A2B agonist; cardioprotective

Chemical Name: 2-[[6-Amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]-acetamide

Purity: ≥98%

Product Details
Citations (11)
Supplemental Products
Reviews

Biological Activity

Potent adenosine A2B receptor agonist (EC50 = 2.83 nM for murine A2B receptor). Displays selectivity for A2B over A1, A2A and A3 receptors. Decreases fMLP-induced superoxide production in neutrophils at low concentrations (1-10 nM). Cardioprotective; attenuates infarct size in a mouse model of myocardial ischemia. Exhibits ERK1/2-biased agonism.

Technical Data

M.Wt:
379.44
Formula:
C19H17N5O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
910487-58-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for BAY 60-6583

The citations listed below are publications that use Tocris products. Selected citations for BAY 60-6583 include:

11 Citations: Showing 1 - 10

  1. Adenosine A2A receptor stimulation restores cell functions and differentiation in Niemann-Pick type C-like oligodendrocytes.
    Authors: Nuccio Et al.
    Sci Rep  2019;9:9782
  2. Dysregulation of ectonucleotidase-mediated extracellular adenosine during postmenopausal bone loss.
    Authors: Shih Et al.
    Sci Adv  2019;5:eaax1387
  3. Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension.
    Authors: Mertens Et al.
    Front Physiol  2018;9:555
  4. Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors.
    Authors: Jain Et al.
    Am J Physiol Endocrinol Metab  2018;315:E357
  5. Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent.
    Authors: Song
    Nat Commun  2017;8:14108
  6. Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome.
    Authors: Asano
    Scientific Reports  2017;7:40214
  7. Differences in the Phosphorylation-Dependent Regulation of Prenylation of Rap1A and Rap1B.
    Authors: Wilson Et al.
    J Mol Biol  2016;428:4929
  8. A2B adenosine receptors stimulate IL-6 production in primary murine microglia through p38 MAPKkinase pathway.
    Authors: Merighi
    Pharmacological Res  2016;117:9
  9. Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis.
    Authors: Aherne Et al.
    Autophagy  2015;8:1324
  10. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors.
    Authors: Perez-Aso Et al.
    Arthritis Res Ther  2015;17:249

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