BAY 60-6583
Chemical Name: 2-[[6-Amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]-acetamide
Purity: ≥98%
Biological Activity
Potent adenosine A2B receptor agonist (EC50 = 2.83 nM for murine A2B receptor). Displays selectivity for A2B over A1, A2A and A3 receptors. Decreases fMLP-induced superoxide production in neutrophils at low concentrations (1-10 nM). Cardioprotective; attenuates infarct size in a mouse model of myocardial ischemia. Exhibits ERK1/2-biased agonism.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors.
Eckle et al.
Circulation, 2007;115:1581 -
A role for the low-affinity A2B adenosine receptor in regulating superoxide generation by murine neutrophils.
van der Hoeven et al.
J.Pharmacol.Exp.Ther., 2011;338:1004 -
Characterization of the A2B adenosine receptor from mouse, rabbit, and dog.
Auchampach et al.
J.Pharmacol.Exp.Ther., 2009;329:2 -
Probing biased/partial agonism at the G protein-coupled A2B adenosine receptor.
Gao et al.
Biochem. Pharmacol., 2014;90:297
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Citations for BAY 60-6583
The citations listed below are publications that use Tocris products. Selected citations for BAY 60-6583 include:
7 Citations: Showing 1 - 7
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Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent.
Authors: Song
Nat Commun 2017;8:14108
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Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome.
Authors: Asano
Scientific Reports 2017;7:40214
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Differences in the Phosphorylation-Dependent Regulation of Prenylation of Rap1A and Rap1B.
Authors: Wilson Et al.
J Mol Biol 2016;428:4929
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A2B adenosine receptors stimulate IL-6 production in primary murine microglia through p38 MAPKkinase pathway.
Authors: Merighi
Pharmacological Res 2016;117:9
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Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis.
Authors: Aherne Et al.
Autophagy 2015;8:1324
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Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors.
Authors: Perez-Aso Et al.
Arthritis Res Ther 2015;17:249
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Blockade of A2b adenosine receptor reduces tumor growth and immune suppression mediated by myeloid-derived suppressor cells in a mouse model of melanoma.
Authors: Iannone Et al.
Neoplasia 2013;15:1400
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