Potent adenosine A2B
receptor agonist (EC50
= 2.83 nM for murine A2B
receptor). Displays selectivity for A2B
receptors. Decreases fMLP-induced superoxide production in neutrophils at low concentrations (1-10 nM). Cardioprotective; attenuates infarct size in a mouse model of myocardial ischemia.
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Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors.
Eckle et al.
A role for the low-affinity A2B adenosine receptor in regulating superoxide generation by murine neutrophils.
van der Hoeven et al.
Characterization of the A2B adenosine receptor from mouse, rabbit, and dog.
Auchampach et al.
The citations listed below are publications that use Tocris products. Selected citations for BAY 60-6583 include:
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