NECA

  ( 17 citations )    
Product Datasheet
Catalog Number:1691
Alternate Names:5'-N-Ethylcarboxamidoadenosine
Chemical Name:1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide
Product Details
Citations (17)
Supplemental Products
Reviews
Biological Activity
High affinity adenosine receptor agonist (Ki values are 6.2, 14, and 20 nM for human A3, A1 and A2A receptors respectively; EC50 = 2.4 μM for human A2B). Inhibits platelet aggregation and is centrally active in vivo.
Technical Data
  • M.Wt:
    308.3
  • Formula:
    C12H16N6O4
  • Solubility:
    Soluble to 40 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    35920-39-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for NECA include:

17 Citations: Showing 1 - 10
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  1. Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent.
    Authors: Song
    Nat Commun  2017;8:14108
  2. Critical role for adenosine receptor A2a in β-cell proliferation.
    Authors: Schulz Et al.
    Mol Metab  2016;5:1138
  3. A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier.
    Authors: Kim and Bynoe
    J Clin Invest  2016;126:1717
  4. A2A Adenosine Receptor Regulates the Human Blood-Brain Barrier Permeability.
    Authors: Kim and Bynoe
    Am J Respir Cell Mol Biol  2015;52:664
  5. Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation.
    Authors: Welihinda and Amento
    J Inflamm (Lond)  2014;11:37
  6. Enhanced brain distribution of modified aspartoacylase.
    Authors: Poddar Et al.
    Mol Genet Metab  2014;113:219
  7. NTPDase1 activity attenuates microglial phagocytosis.
    Authors: Bulavina Et al.
    Purinergic Signal  2013;9:199
  8. Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury.
    Authors: Aggarwal Et al.
    PLoS One  2013;48:635
  9. Autocrine adenosine signaling promotes regulatory T cell-mediated renal protection.
    Authors: Kinsey Et al.
    J Am Soc Nephrol  2012;23:1528
  10. Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury.
    Authors: Pedroza Et al.
    J Clin Immunol  2011;6:e22667
  11. Disparity in FcηRI-induced degranulation of primary human lung and skin mast cells exposed to adenosine.
    Authors: Gomez Et al.
    Nature  2011;31:479
  12. Adenosine receptor signaling modulates permeability of the blood-brain barrier.
    Authors: Carman Et al.
    J Neurosci  2011;31:13272
  13. CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression.
    Authors: Jin Et al.
    Cancer Res  2010;70:2245
  14. Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
    Authors: Garavaglia Et al.
    BMC Neurosci  2010;11:7
  15. Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts.
    Authors: Xi Et al.
    J Mol Cell Cardiol  2009;47:684
  16. Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation.
    Authors: Clark Et al.
    J Neurosci  2009;29:11237
  17. Calcium increases in retinal glial cells evoked by light-induced neuronal activity.
    Authors: Newman
    Mol Neurobiol  2005;25:5502
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