Catalog Number: 1691
Alternate Names: 5'-N-Ethylcarboxamidoadenosine
Chemical Name: 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide
Biological Activity
High affinity adenosine receptor agonist (Ki values are 6.2, 14, and 20 nM for human A3, A1 and A2A receptors respectively; EC50 = 2.4 μM for human A2B). Inhibits platelet aggregation and is centrally active in vivo.
Technical Data
  • M.Wt:
    308.3
  • Formula:
    C12H16N6O4
  • Solubility:
    Soluble to 40 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    35920-39-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 5'-N-ethylcarboxamidoadenosine: a potent inhibitor of human platelet aggregation.
    Cusack and Hourani
    Br.J.Pharmacol., 1981;72:443
  2. Adenosine receptors and their ligands.
    Klot
    Naunyn Schmiedebergs Arch.Pharmacol., 2000;362:382
  3. Adenosine agonists CGS21680 and NECA inhibit the initiation of cocaine self-administration.
    Knapp et al.
    Pharmacol.Biochem.Behav., 2001;68:797
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NECA include:

14 Citations: Showing 1 - 10
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  1. Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent.
    Authors: Song
    Nat Commun 2017;8:14108
  2. A2A Adenosine Receptor Regulates the Human Blood-Brain Barrier Permeability.
    Authors: Kim and Bynoe
    Am J Respir Cell Mol Biol 2015;52:664
  3. Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation.
    Authors: Welihinda and Amento
    J Inflamm (Lond) 2014;11:37
  4. Enhanced brain distribution of modified aspartoacylase.
    Authors: Poddar Et al.
    Mol Genet Metab 2014;113:219
  5. NTPDase1 activity attenuates microglial phagocytosis.
    Authors: Bulavina Et al.
    Purinergic Signal 2013;9:199
  6. Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury.
    Authors: Aggarwal Et al.
    PLoS One 2013;48:635
  7. Autocrine adenosine signaling promotes regulatory T cell-mediated renal protection.
    Authors: Kinsey Et al.
    J Am Soc Nephrol 2012;23:1528
  8. Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury.
    Authors: Pedroza Et al.
    J Clin Immunol 2011;6:e22667
  9. Disparity in FcηRI-induced degranulation of primary human lung and skin mast cells exposed to adenosine.
    Authors: Gomez Et al.
    Nature 2011;31:479
  10. CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression.
    Authors: Jin Et al.
    Cancer Res 2010;70:2245
  11. Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
    Authors: Garavaglia Et al.
    BMC Neurosci 2010;11:7
  12. Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts.
    Authors: Xi Et al.
    J Mol Cell Cardiol 2009;47:684
  13. Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation.
    Authors: Clark Et al.
    J Neurosci 2009;29:11237
  14. Calcium increases in retinal glial cells evoked by light-induced neuronal activity.
    Authors: Newman
    Mol Neurobiol 2005;25:5502
Expand to show all 14 Citations

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