Catalog Number: 1691
Alternate Names: 5'-N-Ethylcarboxamidoadenosine
Chemical Name: 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide
Biological Activity
High affinity adenosine receptor agonist (Ki values are 6.2, 14, and 20 nM for human A3, A1 and A2A receptors respectively; EC50 = 2.4 μM for human A2B). Inhibits platelet aggregation and is centrally active in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 40 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 5'-N-ethylcarboxamidoadenosine: a potent inhibitor of human platelet aggregation.
    Cusack and Hourani
    Br.J.Pharmacol., 1981;72:443
  2. Adenosine receptors and their ligands.
    Naunyn Schmiedebergs Arch.Pharmacol., 2000;362:382
  3. Adenosine agonists CGS21680 and NECA inhibit the initiation of cocaine self-administration.
    Knapp et al.
    Pharmacol.Biochem.Behav., 2001;68:797

The citations listed below are publications that use Tocris products. Selected citations for NECA include:

Showing Results 1 - 10 of 13

  1. A2A Adenosine Receptor Regulates the Human Blood-Brain Barrier Permeability.
    Authors: Kim and Bynoe
    Am J Respir Cell Mol Biol
  2. Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation.
    Authors: Welihinda and Amento
    J Inflamm (Lond)
  3. Enhanced brain distribution of modified aspartoacylase.
    Authors: Poddar Et al.
    Mol Genet Metab
  4. NTPDase1 activity attenuates microglial phagocytosis.
    Authors: Bulavina Et al.
    Purinergic Signal
  5. Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury.
    Authors: Aggarwal Et al.
    PLoS One
  6. Autocrine adenosine signaling promotes regulatory T cell-mediated renal protection.
    Authors: Kinsey Et al.
    J Am Soc Nephrol
  7. Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury.
    Authors: Pedroza Et al.
    J Clin Immunol
  8. Disparity in FcηRI-induced degranulation of primary human lung and skin mast cells exposed to adenosine.
    Authors: Gomez Et al.
  9. CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression.
    Authors: Jin Et al.
    Cancer Res
  10. Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
    Authors: Garavaglia Et al.
    BMC Neurosci
  11. Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts.
    Authors: Xi Et al.
    J Mol Cell Cardiol
  12. Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation.
    Authors: Clark Et al.
    J Neurosci
  13. Calcium increases in retinal glial cells evoked by light-induced neuronal activity.
    Authors: Newman
    Mol Neurobiol
Expand to show all
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