Chemical Name: N-Ethyl-4-[(3S)-3-methyl-4-morpholinyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide
Biological ActivityBAY 707 is a potent and selective MTH1 inhibitor (IC50 = 2.3 nM); exhibits no significant activity at 1 μM concentration against a panel of 97 kinases. BAY 707 is cell-permeable and active in vivo, and displays no antitumor activity in vitro or in vivo.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 707 is reviewed on the chemical probes website.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Creation of a novel class of potent and selective MutT Homologue 1 (MTH1) inhibitors using fragment-based screening and structure-based drug design.
Rahm et al.
Novel class of potent and cellularly active inhibitors devalidates MTH1 as broad-spectrum cancer target.
Ellermann et al.
ACS Chem.Biol., 2017;12:1986
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