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2 results for "MTH1 Inhibitors" in Products
MTH1 Inhibitors
MTH1 (MutT homolog-1; NUDT1), EC 3.6.1.56, is an oxidized purine nucleoside triphosphatase, which is part of the Nudix hydrolase family. MTH1 hydrolyzes cytotoxic oxidized nucleoside triphosphates (dNTPs), such as 2-OH-dATP, preventing them from becoming mis-incorporated into DNA during replication or repair, thus promoting cell survival.
Redox dysfunction is common in cancer cells, owing to their altered metabolism. This results in an excess of reactive oxygen species (ROS), which damage free ...
MTH1 inhibitor
| Chemical Name: | 3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine |
| Purity: | ≥98% |
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Potent and selective MTH1 inhibitor
| Chemical Name: | N-Ethyl-4-[(3S)-3-methyl-4-morpholinyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide |
| Purity: | ≥98% |
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