BAZ2-ICR

Tocris Bioscience | Catalog # 5266

Selective BAZ2 inhibitor
Tocris Bioscience

Key Product Details

Description

Selective BAZ2 inhibitor
View all Bromodomain Inhibitors »

Product Description

BAZ2-ICR is a selective BAZ2 bromodomain inhibitor (IC50 values are 130 and 180 nM for BAZ2A and BAZ2B respectively). Exhibits 15-fold selectivity for the BAZ2 bromodomain over the CERC2 bromodomain and >100-fold selectivity over a range of other bromodomains. Accelerates FRAP recovery in a BAZ2A FRAP assay.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAZ2-ICR probe summary on the SGC website.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAZ2-ICR is reviewed on the chemical probes website.

Product Specifications for BAZ2-ICR

Molecular Weight

357.41

Formula

C20H19N7

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[4-(1-Methyl-1H-pyrazole-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-imidazol-5-yl]benzonitrile

CAS Number

1665195-94-7

PubChem ID

91654625

InChI Key

RRZVGDGTWNQAPW-UHFFFAOYSA-N

SMILES

CN(N=C4)C=C4CCN1C=NC(C3=CN(C)N=C3)=C1C2=CC=C(C#N)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.74 100
Ethanol 35.74 100

Preparing Stock Solutions for BAZ2-ICR

The following data is based on the product molecular weight 357.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.80 mL 13.99 mL 27.98 mL
5 mM 0.56 mL 2.80 mL 5.60 mL
10 mM 0.28 mL 1.40 mL 2.80 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for BAZ2-ICR

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BAZ2-ICR

For research use only

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