Catalog Number: 5027
Chemical Name: 2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid
Biological Activity
Inhibitor of L-type amino acid transporter LAT1. Suppresses growth and induces apoptosis via activation of caspases in KB, Saos2 and C6 cancer cell lines.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. BCH, an inhibitor of system L amino acid transporters, induces apoptosis in cancer cells.
    Kim et al.
    Biol.Pharm.Bull., 2008;31:1096
  2. L-type amino acid transporter-1 overexpression and melphalan sensitivity in Barrett's adenocarcinoma.
    Lin et al.
    Neoplasia, 2004;6:74
  3. L-type amino acid transporters in two intestinal epithelial cell lines function as exchangers with neutral amino acids.
    Fraga et al.
    J.Nutr., 2002;132:733
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