Catalog Number: 0956
Chemical Name: N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide
Biological Activity
σ1 receptor antagonist, exhibiting a similar binding profile to that of BD 1063 (Cat. No. 0883) but with higher affinity (approximately 10-fold) at both σ1 and σ2 sites.
Technical Data
  • M.Wt:
    437.04
  • Formula:
    C13H20Cl2N2.2HBr
  • Solubility:
    Soluble to 50 mM in water and to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    138356-21-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of trazodone on neurotransmitter release from rat mossy fibre cerebellar synaptosomes.
    Garrone et al.
    Eur.J.Pharmacol., 2000;400:35
  2. Involvement of the sigma1 receptor in the cocaine-induced conditioned place preference.
    Romieu et al.
    Neuroreport, 2000;11:2885
  3. Characterisation of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism.
    Matsumoto et al.
    Eur.J.Pharmacol., 1995;280:301
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BD 1047 dihydrobromide include:

14 Citations: Showing 1 - 10
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  1. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
    Authors: Rodríguez-Muñoz Et al.
    Int J Neuropsychopharmacol 2015;6:35458
  2. Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan.
    Authors: Nguyen Et al.
    PLoS One 2014;9:e89985
  3. Effects of BD1047, aσ1 receptor antagonist, on the expression of mTOR, Camk2γ and GSK-3β in fluvoxamine-treated N2a cells.
    Authors: Su Et al.
    Oncotarget 2014;7:435
  4. σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons.
    Authors: Pan Et al.
    Exp Ther Med 2014;350:290
  5. NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids.
    Authors: Gear Et al.
    Neuroscience 2014;257:139
  6. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    Korean J Physiol Pharmacol 2014;17:1943
  7. Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine.
    Authors: Kourrich Et al.
    Cell 2013;152:236
  8. Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors.
    Authors: Hiranita Et al.
    J Pharmacol Exp Ther 2011;339:662
  9. σ-1 Receptor Antagonist BD1047 Reduces Allodynia and Spinal ERK Phosphorylation Following Chronic Compression of Dorsal Root Ganglion in Rats.
    Authors: Son and Kwon
    J Neurophysiol 2010;14:359
  10. Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABA receptors.
    Authors: Yoon Et al.
    Br J Pharmacol 2009;157:666
  11. The Antinociceptive Effect of σ-1 Receptor Antagonist, BD1047, in a Capsaicin Induced Headache Model in Rats.
    Authors: Kwon Et al.
    Br J Ophthalmol 2009;13:425
  12. Protective effects of the σ agonist Pre-084 in the rat retina.
    Authors: Cantarella Et al.
    Korean J Physiol Pharmacol 2007;91:1382
  13. The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan.
    Authors: Shin Et al.
    Br J Pharmacol 2005;144:908
  14. Antitussive activity of sigma-1 receptor agonists in the guinea-pig.
    Authors: Brown Et al.
    Br J Pharmacol 2004;141:233
Expand to show all 14 Citations

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