Catalog Number: 0956
Chemical Name: N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide
Biological Activity
σ1 receptor antagonist, exhibiting a similar binding profile to that of BD 1063 (Cat. No. 0883) but with higher affinity (approximately 10-fold) at both σ1 and σ2 sites.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water and to 50 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of trazodone on neurotransmitter release from rat mossy fibre cerebellar synaptosomes.
    Garrone et al.
    Eur.J.Pharmacol., 2000;400:35
  2. Involvement of the sigma1 receptor in the cocaine-induced conditioned place preference.
    Romieu et al.
    Neuroreport, 2000;11:2885
  3. Characterisation of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism.
    Matsumoto et al.
    Eur.J.Pharmacol., 1995;280:301

The citations listed below are publications that use Tocris products. Selected citations for BD 1047 dihydrobromide include:

Showing Results 1 - 10 of 14

  1. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
    Authors: Rodríguez-Muñoz Et al.
    Int J Neuropsychopharmacol
  2. Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan.
    Authors: Nguyen Et al.
    PLoS One
  3. Effects of BD1047, aσ1 receptor antagonist, on the expression of mTOR, Camk2γ and GSK-3β in fluvoxamine-treated N2a cells.
    Authors: Su Et al.
  4. σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons.
    Authors: Pan Et al.
    Exp Ther Med
  5. NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids.
    Authors: Gear Et al.
  6. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    Korean J Physiol Pharmacol
  7. Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine.
    Authors: Kourrich Et al.
  8. Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors.
    Authors: Hiranita Et al.
    J Pharmacol Exp Ther
  9. σ-1 Receptor Antagonist BD1047 Reduces Allodynia and Spinal ERK Phosphorylation Following Chronic Compression of Dorsal Root Ganglion in Rats.
    Authors: Son and Kwon
    J Neurophysiol
  10. Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABA receptors.
    Authors: Yoon Et al.
    Br J Pharmacol
  11. The Antinociceptive Effect of σ-1 Receptor Antagonist, BD1047, in a Capsaicin Induced Headache Model in Rats.
    Authors: Kwon Et al.
    Br J Ophthalmol
  12. Protective effects of the σ agonist Pre-084 in the rat retina.
    Authors: Cantarella Et al.
    Korean J Physiol Pharmacol
  13. The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan.
    Authors: Shin Et al.
    Br J Pharmacol
  14. Antitussive activity of sigma-1 receptor agonists in the guinea-pig.
    Authors: Brown Et al.
    Br J Pharmacol
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