BD 1047 dihydrobromide

  ( 18 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:0956
Chemical Name:N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide
Product Details
Citations (18)
Supplemental Products
Reviews
Biological Activity
σ1 receptor antagonist, exhibiting a similar binding profile to that of BD 1063 (Cat. No. 0883) but with higher affinity (approximately 10-fold) at both σ1 and σ2 sites.
Technical Data
  • M.Wt:
    437.04
  • Formula:
    C13H20Cl2N2.2HBr
  • Solubility:
    Soluble to 50 mM in water and to 50 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at +4°C
  • CAS No:
    138356-21-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for BD 1047 dihydrobromide include:

18 Citations: Showing 1 - 10
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  1. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
    Authors: Rodríguez-Muñoz Et al.
    Int J Neuropsychopharmacol  2015;6:35458
  2. Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan.
    Authors: Nguyen Et al.
    PLoS One  2014;9:e89985
  3. Effects of BD1047, aσ1 receptor antagonist, on the expression of mTOR, Camk2γ and GSK-3β in fluvoxamine-treated N2a cells.
    Authors: Su Et al.
    Oncotarget  2014;7:435
  4. σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons.
    Authors: Pan Et al.
    Exp Ther Med  2014;350:290
  5. NMDA receptors are upregulated and trafficked to the plasma membrane after sigma-1 receptor activation in the rat hippocampus.
    Authors: Pabba Et al.
    J Neurosci  2014;34:11325
  6. NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids.
    Authors: Gear Et al.
    Neuroscience  2014;257:139
  7. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    Korean J Physiol Pharmacol  2014;17:1943
  8. σ1 receptors activate astrocytes via p38 MAPK phosphorylation leading to the development of mechanical allodynia in a mouse model of neuropathic pain.
    Authors: Moon Et al.
    Br J Pharmacol  2014;171:5881
  9. Activation and inhibition of transient receptor potential TRPM3-induced gene transcription.
    Authors: Lesch Et al.
    Br J Pharmacol  2014;171:2645
  10. Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine.
    Authors: Kourrich Et al.
    Cell  2013;152:236
  11. Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors.
    Authors: Hiranita Et al.
    J Pharmacol Exp Ther  2011;339:662
  12. Spinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: involvement of PKC-dependent GluN1 phosphorylation.
    Authors: Roh Et al.
    Br J Pharmacol  2011;163:1707
  13. σ-1 Receptor Antagonist BD1047 Reduces Allodynia and Spinal ERK Phosphorylation Following Chronic Compression of Dorsal Root Ganglion in Rats.
    Authors: Son and Kwon
    J Neurophysiol  2010;14:359
  14. Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABA receptors.
    Authors: Yoon Et al.
    Br J Pharmacol  2009;157:666
  15. The Antinociceptive Effect of σ-1 Receptor Antagonist, BD1047, in a Capsaicin Induced Headache Model in Rats.
    Authors: Kwon Et al.
    Br J Ophthalmol  2009;13:425
  16. Protective effects of the σ agonist Pre-084 in the rat retina.
    Authors: Cantarella Et al.
    Korean J Physiol Pharmacol  2007;91:1382
  17. The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan.
    Authors: Shin Et al.
    Br J Pharmacol  2005;144:908
  18. Antitussive activity of sigma-1 receptor agonists in the guinea-pig.
    Authors: Brown Et al.
    Br J Pharmacol  2004;141:233
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