BD 1047 dihydrobromide

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BD 1047 dihydrobromide | CAS No. 138356-21-5 | Sigma1 Receptor Antagonists
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Description: σ1 selective antagonist

Chemical Name: N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide

Purity: ≥99%

Product Details
Citations (23)

Biological Activity

BD 1047 dihydrobromide is a σ1 receptor antagonist, exhibiting a similar binding profile to that of BD 1063 (Cat. No. 0883) but with higher affinity (approximately 10-fold) at both σ1 and σ2 sites.

Technical Data

Soluble to 50 mM in water and to 50 mM in DMSO
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for BD 1047 dihydrobromide

The citations listed below are publications that use Tocris products. Selected citations for BD 1047 dihydrobromide include:

23 Citations: Showing 1 - 10

  1. Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP3-Evoked Ca2+ Signals through Sigma-1 Receptors.
    Authors: Brailoiu Et al.
    Cell Rep  2019;26:330
  2. The Sigma-1 Receptor Antagonist, S1RA, Reduces Stroke Damage, Ameliorates Post-Stroke Neurological Deficits and Suppresses the Overexpression of MMP-9.
    Authors: Sánchez-Blázquez Et al.
    Mol Neurobiol  2018;55:4940
  3. Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice.
    Authors: Sánchez-Blázquez Et al.
    Int J Neuropsychopharmacol  2018;21:938
  4. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
    Authors: Rodríguez-Muñoz Et al.
    Int J Neuropsychopharmacol  2015;6:35458
  5. Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan.
    Authors: Nguyen Et al.
    PLoS One  2014;9:e89985
  6. Effects of BD1047, aσ1 receptor antagonist, on the expression of mTOR, Camk2γ and GSK-3β in fluvoxamine-treated N2a cells.
    Authors: Su Et al.
    Oncotarget  2014;7:435
  7. σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons.
    Authors: Pan Et al.
    Exp Ther Med  2014;350:290
  8. NMDA receptors are upregulated and trafficked to the plasma membrane after sigma-1 receptor activation in the rat hippocampus.
    Authors: Pabba Et al.
    J Neurosci  2014;34:11325
  9. NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids.
    Authors: Gear Et al.
    Neuroscience  2014;257:139
  10. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    Korean J Physiol Pharmacol  2014;17:1943
  11. σ1 receptors activate astrocytes via p38 MAPK phosphorylation leading to the development of mechanical allodynia in a mouse model of neuropathic pain.
    Authors: Moon Et al.
    Br J Pharmacol  2014;171:5881
  12. Activation and inhibition of transient receptor potential TRPM3-induced gene transcription.
    Authors: Lesch Et al.
    Br J Pharmacol  2014;171:2645
  13. Afobazole activation of σ-1 receptors modulates neuronal responses to amyloid-β25-35.
    Authors: Behensky Et al.
    J Pharmacol Exp Ther  2013;347:468
  14. Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma-1 receptor ligands.
    Authors: Amer Et al.
    Br J Pharmacol  2013;168:1445
  15. Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine.
    Authors: Kourrich Et al.
    Cell  2013;152:236
  16. Decreases in cocaine self-administration with dual inhibition of the DA transporter and σ receptors.
    Authors: Hiranita Et al.
    J Pharmacol Exp Ther  2011;339:662
  17. Spinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: involvement of PKC-dependent GluN1 phosphorylation.
    Authors: Roh Et al.
    Br J Pharmacol  2011;163:1707
  18. σ-1 Receptor Antagonist BD1047 Reduces Allodynia and Spinal ERK Phosphorylation Following Chronic Compression of Dorsal Root Ganglion in Rats.
    Authors: Son and Kwon
    J Neurophysiol  2010;14:359
  19. Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABA receptors.
    Authors: Yoon Et al.
    Br J Pharmacol  2009;157:666
  20. The Antinociceptive Effect of σ-1 Receptor Antagonist, BD1047, in a Capsaicin Induced Headache Model in Rats.
    Authors: Kwon Et al.
    Br J Ophthalmol  2009;13:425
  21. Protective effects of the σ agonist Pre-084 in the rat retina.
    Authors: Cantarella Et al.
    Korean J Physiol Pharmacol  2007;91:1382
  22. The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan.
    Authors: Shin Et al.
    Br J Pharmacol  2005;144:908
  23. Antitussive activity of sigma-1 receptor agonists in the guinea-pig.
    Authors: Brown Et al.
    Br J Pharmacol  2004;141:233


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