Bendamustine hydrochloride
Chemical Name: 5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid hydrochloride
Purity: ≥98%
Biological Activity
Cytostatic agent that displays activity in non-Hodgkin's lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those of purine analogs.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Bendamustine.
Keating et al.
Nat.Rev.Drug Discov., 2008;7:473 -
Bendamustine therapy in chronic lymphocytic leukemia.
Masiello and Tulpule
Expert Opin.Pharmacother., 2009;10:1687 -
In vitro evaluation of bendamu. induced apoptosis in B-chronic lymphocytic leukemia.
Schwanen et al.
Leukemia., 2002;16:2096
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Bendamustine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.