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Bendamustine hydrochloride

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Bendamustine hydrochloride | CAS No. 3543-75-7 | Apoptosis Inducer Compounds
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Description: Cytostatic agent; exhibits DNA alkylating and purine analog properties

Chemical Name: 5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid hydrochloride

Purity: ≥98%

Product Details
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Bendamustine hydrochloride is a cytostatic agent that displays activity in non-Hodgkin's lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those of purine analogs.

Technical Data

M.Wt:
394.72
Formula:
C16H21Cl2N3O2.HCl
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
3543-75-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Bendamustine.
    Keating et al.
    Nat.Rev.Drug Discov., 2008;7:473
  2. Bendamustine therapy in chronic lymphocytic leukemia.
    Masiello and Tulpule
    Expert Opin.Pharmacother., 2009;10:1687
  3. In vitro evaluation of bendamu. induced apoptosis in B-chronic lymphocytic leukemia.
    Schwanen et al.
    Leukemia., 2002;16:2096

Product Datasheets

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Bendamustine termporarily halts growth of melanoma cells in vitro
By Anonymous on 02/14/2019
Application: Species: Human

Bendamustine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.

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