Catalog Number: 3681
Chemical Name: 5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid hydrochloride
Biological Activity
Cytostatic agent that displays activity in non-Hodgkin's lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those of purine analogs.
Technical Data
  • M.Wt:
    394.72
  • Formula:
    C16H21Cl2N3O2.HCl
  • Solubility:
    Soluble to 25 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    3543-75-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. In vitro evaluation of bendamustine induced apoptosis in B-chronic lymphocytic leukemia.
    Schwanen et al.
    Leukemia., 2002;16:2096
  2. Bendamustine.
    Keating et al.
    Nat.Rev.Drug Discov., 2008;7:473
  3. Bendamustine therapy in chronic lymphocytic leukemia.
    Masiello and Tulpule
    Expert Opin.Pharmacother., 2009;10:1687

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