Chemical Name: 5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid hydrochloride
Biological ActivityBendamustine hydrochloride is a cytostatic agent that displays activity in non-Hodgkin's lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those of purine analogs.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Keating et al.
Nat.Rev.Drug Discov., 2008;7:473
Bendamustine therapy in chronic lymphocytic leukemia.
Masiello and Tulpule
Expert Opin.Pharmacother., 2009;10:1687
In vitro evaluation of bendamu. induced apoptosis in B-chronic lymphocytic leukemia.
Schwanen et al.
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Bendamustine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.