Chemical Name: N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride
Biological ActivityNa+/Ca2+ exhanger (NCX) inhibitor (IC50 ~ 100 nM); TRPP3 channel blocker (IC50 = 1.1 μM for inhibition of Ca2+-activated TRPP3 channel activity). Also non-selective Deg/ENaC family blocker; reduces mechanosensitivity of colonic afferents. More potent derivative of amiloride (Cat. No. 0890).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Inhibition of TRPP3 channel by amiloride and analogs.
Dai et al.
Characterization of a Na+-Ca2+ exchanger in podocytes.
Fischer et al.
Acid sensing ion channels 2 and 3 are required for inhibition of visceral nociceptors by benzamil.
Page et al.
Citation for Benzamil
The citations listed below are publications that use Tocris products. Selected citations for Benzamil include:
1 Citation: Showing 1 - 1
Determination of system level alterations in host transcriptome due to Zika virus (ZIKV) Infection in retinal pigment epithelium.
Sci Rep 2018;8:11209
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