Chemical Name: N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride
Biological ActivityBenzamil is a Na+/Ca2+ exhanger (NCX) inhibitor (IC50 ~ 100 nM); TRPP3 channel blocker (IC50 = 1.1 μM for inhibition of Ca2+-activated TRPP3 channel activity). Also non-selective Deg/ENaC family blocker; reduces mechanosensitivity of colonic afferents. More potent derivative of amiloride (Cat. No. 0890).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterization of a Na+-Ca2+ exchanger in podocytes.
Fischer et al.
Acid sensing ion channels 2 and 3 are required for inhibition of visceral nociceptors by benzamil.
Page et al.
Inhibition of TRPP3 channel by amil. and analogs.
Dai et al.
Citations for Benzamil
The citations listed below are publications that use Tocris products. Selected citations for Benzamil include:
5 Citations: Showing 1 - 5
Development of Orthogonal Linear Separation Analysis (OLSA) to Decompose Drug Effects into Basic Components.
Authors: Mizuno Et al.
Sci Rep 2019;9:1824
Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity.
Authors: Panja Et al.
Neuropathol Appl Neurobiol 2019;45:141
Determination of system level alterations in host transcriptome due to Zika virus (ZIKV) Infection in retinal pigment epithelium.
Sci Rep 2018;8:11209
Knockout of mitochondrial voltage-dependent anion channel type 3 increases reactive oxygen species (ROS) levels and alters renal sodium transport.
Authors: Zou Et al.
J Biol Chem 2018;293:1666
Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes.
Authors: Agarwal Et al.
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