Benzamil

Key Product Details

Product Description

Benzamil is a Na⁺/Ca²⁺ exhanger (NCX) inhibitor (IC₅₀ ~ 100 nM); TRPP3 channel blocker (IC₅₀ = 1.1 μM for inhibition of Ca²⁺-activated TRPP3 channel activity). Also non-selective Deg/ENaC family blocker; reduces mechanosensitivity of colonic afferents. More potent derivative of amiloride (Cat. No. 0890).

Product Specifications for Benzamil

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Benzamil

The following data is based on the product molecular weight 356.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.81 mL	14.04 mL	28.07 mL
5 mM	0.56 mL	2.81 mL	5.61 mL
10 mM	0.28 mL	1.40 mL	2.81 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

• Fischer Characterization of a Na⁺-Ca²⁺ exchanger in podocytes. Nephrol.Dial.Transplant. 2002 PMID: 12270979
• Page Acid sensing ion channels 2 and 3 are required for inhibition of visceral nociceptors by benzamil. Pain 2007 PMID: 17467171
• Dai Inhibition of TRPP3 channel by amil. and analogs. Mol.Pharmacol. 2007 PMID: 17804601

Product Documents for Benzamil