Catalog Number: 3380
Chemical Name: N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride
Biological Activity
Na+/Ca2+ exhanger (NCX) inhibitor (IC50 ~ 100 nM); TRPP3 channel blocker (IC50 = 1.1 μM for inhibition of Ca2+-activated TRPP3 channel activity). Also non-selective Deg/ENaC family blocker; reduces mechanosensitivity of colonic afferents. More potent derivative of amiloride (Cat. No. 0890).
Technical Data
  • M.Wt:
    356.21
  • Formula:
    C13H14ClN7O.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in water
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    161804-20-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterization of a Na+-Ca2+ exchanger in podocytes.
    Fischer et al.
    Nephrol.Dial.Transplant., 2002;17:1742
  2. Acid sensing ion channels 2 and 3 are required for inhibition of visceral nociceptors by benzamil.
    Page et al.
    Pain, 2007;133:150
  3. Inhibition of TRPP3 channel by amiloride and analogs.
    Dai et al.
    Mol.Pharmacol., 2007;72:1576
Tocris Small Molecules
Description Application Cat# Citations Images  

Amiloride hydrochloride

0890 3  
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