Amiloride hydrochloride

Catalog # Availability Size / Price Qty
Cat.No. 0890 - Amiloride hydrochloride | C6H8ClN7O.HCl | CAS No. 2016-88-8
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Description: Na+ channel blocker; also I2 imidazoline ligand

Chemical Name: 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride

Purity: ≥98%

Product Details
Citations (3)
Supplemental Products
Reviews (1)

Biological Activity

Na+ channel blocker. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.

Technical Data

Soluble to 10 mM in water with gentle warming
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Evaluation of the role of nitric oxide in acid sensing ion channel mediated cell death.
    Jetti et al.
    Nitric Oxide, 2010;22:213
  2. Inhibition of TRPP3 channel by amiloride and analogs.
    Dai et al.
    Mol.Pharmacol., 2007;72:1576
  3. The pharmacology of mechanogated membrane ion channels.
    Hamill and McBride
    Pharmacol.Rev., 1996;48:231
  4. Amiloride and its analogues as tools in the study of ion transport.
    Kleyman et al.
    J.Membr.Biol., 1988;105:1
  5. A second generation of centrally acting antihypertensive agents act on putative I1-imidazoline receptors.
    Ernsberger et al.
    J.Cardiovasc.Pharmacol., 1992;20:S1

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Citations for Amiloride hydrochloride

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Reviews for Amiloride hydrochloride

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ASIC inhibition on acute brain slices
By Anonymous on 01/10/2018
Species: Mouse

Used to show ASIC channels were not involved in the studied effect. No effect was had, as expected, however it's hard to control for the drug efficacy as we did not show ASIC blockade directly.

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