Amiloride hydrochloride

  ( 3 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:0890
Chemical Name:3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride
Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity
Na+ channel blocker. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.
Technical Data
  • M.Wt:
    266.09
  • Formula:
    C6H8ClN7O.HCl
  • Solubility:
    Soluble to 10 mM in water with gentle warming
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    2016-88-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Amiloride hydrochloride include:

3 Citations: Showing 1 - 3
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  1. Dendritic cell amiloride-sensitive channels mediate sodium-induced inflammation and hypertension.
    Authors: Barbaro
    Cell Rep  2017;21(4):1009
  2. Polycaprolactone/maltodextrin nanocarrier for intracellular drug delivery: formulation, uptake mechanism, internalization kinetics, and subcellular localization.
    Authors: Korang-Yeboah Et al.
    J Neurosci  2015;10:4763
  3. Antinociceptive effects of amiloride and benzamil in neuropathic pain model rats.
    Authors: Jeong Et al.
    Int J Nanomedicine  2013;28:1238

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