Catalog Number: 0890
Chemical Name: 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride
Biological Activity
Na+ channel blocker. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in water with gentle warming
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Amiloride and its analogues as tools in the study of ion transport.
    Kleyman et al.
    J.Membr.Biol., 1988;105:1
  2. Inhibition of TRPP3 channel by amiloride and analogs.
    Dai et al.
    Mol.Pharmacol., 2007;72:1576
  3. The pharmacology of mechanogated membrane ion channels.
    Hamill and McBride
    Pharmacol.Rev., 1996;48:231
  4. Evaluation of the role of nitric oxide in acid sensing ion channel mediated cell death.
    Jetti et al.
    Nitric Oxide, 2010;22:213
  5. Amiloride selectively inhibits the urokinase-type plasminogen activator.
    Vassalli et al.
    , 1987;214:187
  6. A second generation of centrally acting antihypertensive agents act on putative I1-imidazoline receptors.
    Ernsberger et al.
    J.Cardiovasc.Pharmacol., 1992;20:S1

The citations listed below are publications that use Tocris products. Selected citations for Amiloride hydrochloride include:

3 Citations: Showing 1 - 3
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  1. Dendritic cell amiloride-sensitive channels mediate sodium-induced inflammation and hypertension.
    Authors: Barbaro
    Cell?Rep 2017;21(4):1009
  2. Polycaprolactone/maltodextrin nanocarrier for intracellular drug delivery: formulation, uptake mechanism, internalization kinetics, and subcellular localization.
    Authors: Korang-Yeboah Et al.
    J Neurosci 2015;10:4763
  3. Antinociceptive effects of amiloride and benzamil in neuropathic pain model rats.
    Authors: Jeong Et al.
    Int J Nanomedicine 2013;28:1238
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