Amiloride hydrochloride

Catalog # Availability Size / Price Qty
Amiloride hydrochloride | CAS No. 2016-88-8 | Voltage-gated Sodium Channel Blockers
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Description: Na+ channel blocker; also I2 imidazoline ligand

Chemical Name: 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride

Purity: ≥98%

Product Details
Citations (7)
Supplemental Products

Biological Activity

Amiloride hydrochloride is a Na+ channel blocker. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.

Technical Data

Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Evaluation of the role of nitric oxide in acid sensing ion channel mediated cell death.
    Jetti et al.
    Nitric Oxide, 2010;22:213
  2. The pharmacology of mechanogated membrane ion channels.
    Hamill and McBride
    Pharmacol.Rev., 1996;48:231
  3. Amiloride and its analogues as tools in the study of ion transport.
    Kleyman et al.
    J.Membr.Biol., 1988;105:1
  4. A second generation of centrally acting antihypertensive agents act on putative I1-imidazoline receptors.
    Ernsberger et al.
    J.Cardiovasc.Pharmacol., 1992;20:S1
  5. Inhibition of TRPP3 channel by amil. and analogs.
    Dai et al.
    Mol.Pharmacol., 2007;72:1576

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Citations for Amiloride hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Amiloride hydrochloride include:

7 Citations: Showing 1 - 7


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