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β-Lipotropin 61-91

Name: β-Lipotropin 61-91
Brand: Tocris Bioscience
SKU: 8984
Price: 159 USD
Availability: InStock

Tocris Bioscience | Catalog # 8984

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Product Documents

Endogenous opioid peptide; component of the LIP cocktail for preconditioning human β-cells

Technical Data
Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Endogenous opioid peptide; component of the LIP cocktail for preconditioning human β-cells

View all mu Opioid Receptor Agonists »

Product Description

β-Lipotropin 61-91 (or β-Endorphin) is an endogenous opioid peptide with potent antinociceptive activity, physiologically released in response to painful stimuli.

β-Lipotropin 61-91 can be used to study the expression of μ-opioid receptor in organ cultures and to investigate cardiovascular regulation.

In combination with 10 μM Prostaglandin E2 (Cat. No. 2296) and 1 μg/mL IGF-1, β-Lipotropin 61-91 (0.01 μM) constitutes the LIP cocktail, a small molecule mixture used to precondition human β-cells and primary islets, significantly enhancing function and survival when transplanted subcutaneously to female mice.

Product Specifications for β-Lipotropin 61-91

Formula

C₁₅₈H₂₅₁N₃₉O₄₆S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

61214-51-5

PubChem ID

16132316

InChI Key

JMHFFDIMOUKDCZ-NTXHZHDSSA-N

SMILES

O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCSC)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N2[C@@H](CCC2)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC5=CC=C(C=C5)O)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in 20% ethanol / water

Calculators

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Background References

References are publications that support the biological activity of the product.

Bloom Endorphins: profound behavioral effects in rats suggest new etiological factors in mental illness. Science 1976 PMID: 185694
Hill The effects of beta-endorphin (beta-END) on cardiovascular and behavioral dynamics in conscious rats. Brain Res.Bull 2002 PMID: 12372545
Vandana ChemPerturb-seq screen identifies a small molecule cocktail enhancing human beta cell survival after subcutaneous transplantation. CellStemCell 2025 PMID: 40562034

Product Documents for β-Lipotropin 61-91

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for β-Lipotropin 61-91

For research use only

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