Catalog Number: 2296
Chemical Name: (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid
Biological Activity
Endogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Binds with high affinity to EP1, EP2, EP3 and EP4 receptors (Kd values range between ~ 1 - 10 nM). Influences a wide range of processes including inflammation, smooth muscle relaxation, fertility and gastric mucosal integrity. Regulates vertebrate hematopoietic stem cell (HSC) homeostasis.
Technical Data
  • M.Wt:
    352.47
  • Formula:
    C20H32O5
  • Solubility:
    Soluble to 100 mM in DMSO and to 45 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    363-24-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.
    Coleman et al.
    Pharmacol.Rev., 1994;46:205
  2. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.
    North et al.
    , 2007;447:1007
  3. Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation.
    Hata and Breyer
    Pharm.Ther., 2004;103:147
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Prostaglandin E2 include:

7 Citations: Showing 1 - 7
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  1. Organoid culture systems for prostate epithelial and cancer tissue.
    Authors: Drost Et al.
    Proc Natl Acad Sci U S A 2016;11:347
  2. Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity.
    Authors: Gonnermann Et al.
    Oncoimmunology 2015;4:e988460
  3. Organoid models of human and mouse ductal pancreatic cancer.
    Authors: Boj Et al.
    Sci Signal 2015;160:324
  4. In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
    Authors: Bartfeld Et al.
    Nat Protoc 2015;148:126
  5. Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases.
    Authors: Weeber Et al.
    Cell 2015;112:13308
  6. MDMA increases glutamate release and reduces parvalbumin-positive GABAergic cells in the dorsal hippocampus of the rat: role of cyclooxygenase.
    Authors: Anneken Et al.
    Respir Res 2013;8:58
  7. Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+.
    Authors: Wang Et al.
    J Neuroimmune Pharmacol 2012;5:ra26
Tocris Small Molecules
Description Application Cat# Citations Images  

16,16-Dimethyl Prostaglandin E2

4027 1  
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