Catalog Number: 2296
Chemical Name: (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid
Biological Activity
Endogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Binds with high affinity to EP1, EP2, EP3 and EP4 receptors (Kd values range between ~ 1 - 10 nM). Influences a wide range of processes including inflammation, smooth muscle relaxation, fertility and gastric mucosal integrity. Regulates vertebrate hematopoietic stem cell (HSC) homeostasis.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 45 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.
    Coleman et al.
    Pharmacol.Rev., 1994;46:205
  2. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.
    North et al.
    , 2007;447:1007
  3. Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation.
    Hata and Breyer
    Pharm.Ther., 2004;103:147
Tocris Small Molecules
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16,16-Dimethyl Prostaglandin E2

4027 1  
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