Endogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Binds with high affinity to EP1
values range between ~ 1 - 10 nM). Influences a wide range of processes including inflammation, smooth muscle relaxation, fertility and gastric mucosal integrity. Regulates vertebrate hematopoietic stem cell (HSC) homeostasis.
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Classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.
Coleman et al.
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.
North et al.
Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation.
Hata and Breyer
The citations listed below are publications that use Tocris products. Selected citations for Prostaglandin E2 include:
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