Prostaglandin E2

Catalog # Availability Size / Price Qty
2296/10
Prostaglandin E2 | CAS No. 363-24-6 | Prostanoid Receptor Agonists
1 Image
Description: Major endogenous prostanoid
Alternative Names: PGE2

Chemical Name: (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid

Purity: ≥98%

Product Details
Citations (18)
Supplemental Products
Reviews (1)

Biological Activity

Endogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Binds with high affinity to EP1, EP2, EP3 and EP4 receptors (Kd values range between ~ 1 - 10 nM). Influences a wide range of processes including inflammation, smooth muscle relaxation, fertility and gastric mucosal integrity. Regulates vertebrate hematopoietic stem cell (HSC) homeostasis.

Technical Data

M.Wt:
352.47
Formula:
C20H32O5
Solubility:
Soluble to 100 mM in DMSO and to 45 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
363-24-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.
    Coleman et al.
    Pharmacol.Rev., 1994;46:205
  2. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.
    North et al.
    Nature., 2007;447:1007
  3. Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation.
    Hata and Breyer
    Pharm.Ther., 2004;103:147
  4. Identification of multipotent luminal progenitor cells in human prostate organoid cultures.
    Karthaus et al.
    Cell, 2014;159:163
  5. SnapShot: Growing Organoids from Stem Cells.
    Sato et al.
    Cell, 2015;161:1700
  6. Prostaglandin E2 increases lentiviral vector transduction efficiency of adult human hematopoietic stem and progenitor cells.
    Heffner et al.
    Mol.Ther, 2018;26:320

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for Prostaglandin E2

The citations listed below are publications that use Tocris products. Selected citations for Prostaglandin E2 include:

18 Citations: Showing 1 - 10

  1. IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer.
    Authors: Colomer Et al.
    Mol Cell  2019;75:669
  2. A Novel Three-Dimensional Immune Oncology Model for High-Throughput Testing of Tumoricidal Activity.
    Authors: Sherman Et al.
    Front Immunol  2018;9:857
  3. Prostaglandin receptor EP3 regulates cell proliferation and migration with impact on survival of endometrial cancer patients.
    Authors: Zhu
    Oncotarget  2018;9(1):982
  4. Directed Differentiation of Human Induced Pluripotent Stem Cells into Dendritic Cells Displaying Tolerogenic Properties and Resembling the CD141+ Subset.
    Authors: Sachamitr Et al.
    Front Immunol  2018;8:1935
  5. Prostaglandin E2 receptor 3 signaling is induced in placentas with unexplained recurrent pregnancy losses.
    Authors: Ye Et al.
    Endocr Connect  2018;7:749
  6. Human Fetal-Derived Enterospheres Provide Insights on Intestinal Development and a Novel Model to Study Necrotizing Enterocolitis (NEC).
    Authors: Senger Et al.
    Cell Mol Gastroenterol Hepatol  2018;5:549
  7. TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma.
    Authors: Somerville Et al.
    Cell Rep  2018;25:1741
  8. Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer.
    Authors: Al-Taei Et al.
    Oncoimmunology  2017;6:e1268308
  9. Organoid culture of human prostate cancer cell lines LNCaP and C4-2B.
    Authors: Ma Et al.
    Am J Clin Exp Urol  2017;5:25
  10. Stimulation of the pelvic nerve increases bladder capacity in the prostaglandin E2 rat model of overactive bladder.
    Authors: Langdale Et al.
    Am J Physiol Renal Physiol  2017;313:F657

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Tocris Small Molecules

Reviews for Prostaglandin E2

Average Rating: 4 (Based on 1 Review)

5 Star
0%
4 Star
100%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used Prostaglandin E2?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Application prostaglandin E2 on acute brain slices and cultured cells.
By Anonymous on 01/10/2018
Species: Mouse

Application of prostaglandin E2 on brain slices. No effect in our assay but the concentration might have been too low. We had some decent effect on cultured cells.


Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.