Prostaglandin E2
Tocris Bioscience | Catalog # 2296
Key Product Details
Description
Alternative Names
Product Description
Prostaglandin E2 is an endogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Prostaglandin E2 binds with high affinity to EP1, EP2, EP3 and EP4 receptors (Kd values range between ~ 1 - 10 nM). Prostaglandin E2 influences a wide range of processes including inflammation, vasodilation, smooth muscle relaxation, fertility, gastric mucosal integrity and platelet aggregation. Prostaglandin E2 regulates vertebrate hematopoietic stem cell (HSC) homeostasis, acts as viral transduction enhancer and is tumorigenic in some cancers.
Product Specifications for Prostaglandin E2
Molecular Weight
Formula
Storage
Purity
Chemical Name
CAS Number
PubChem ID
InChI Key
SMILES
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.25 | 100 | |
| Ethanol | 15.86 | 45 |
Preparing Stock Solutions for Prostaglandin E2
The following data is based on the product molecular weight 352.47.
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.84 mL | 14.19 mL | 28.37 mL |
| 5 mM | 0.57 mL | 2.84 mL | 5.67 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.84 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
Calculators
Background References
References are publications that support the biological activity of the product. See our Citations tab to view 253 publications citing the usage of this product.
- Heffner Prostaglandin E2 increases lentiviral vector transduction efficiency of adult human hematopoietic stem and progenitor cells. Mol.Ther 2018 PMID: 29102562
- Ke Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer. Tumour Biol. 2016 PMID: 27230680
- Karthaus Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell. 2014 PMID: 25201529
- Sato SnapShot: Growing organoids from stem cells. Cell. 2015 PMID: 26091044
- North Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 2007 PMID: 17581586
- Hata and Breyer Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. Pharm.Ther.
- Coleman Classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol.Rev. 1994 PMID: 7938166
Product Documents for Prostaglandin E2
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for Prostaglandin E2
For research use only
Related Research Areas
Citations for Prostaglandin E2
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Species: HumanAssay Type: In VitroVerified Customer | Posted 09/22/2023Prostaglandin E2 supplementation for organoids media is paramount for some organoid model growth and viability.
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Species: MouseAssay Type: Ex VivoCell Line/Tissue: acute brain slice, cultured cellsVerified Customer | Posted 01/10/2018Application of prostaglandin E2 on brain slices. No effect in our assay but the concentration might have been too low. We had some decent effect on cultured cells.
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