Prostaglandin E2

  ( 8 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:2296
Chemical Name:(5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid
Product Details
Citations (8)
Supplemental Products
Reviews
Biological Activity
Endogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Binds with high affinity to EP1, EP2, EP3 and EP4 receptors (Kd values range between ~ 1 - 10 nM). Influences a wide range of processes including inflammation, smooth muscle relaxation, fertility and gastric mucosal integrity. Regulates vertebrate hematopoietic stem cell (HSC) homeostasis.
Technical Data
  • M.Wt:
    352.47
  • Formula:
    C20H32O5
  • Solubility:
    Soluble to 100 mM in DMSO and to 45 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    363-24-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Prostaglandin E2 include:

8 Citations: Showing 1 - 8
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  1. Prostaglandin receptor EP3 regulates cell proliferation and migration with impact on survival of endometrial cancer patients.
    Authors: Zhu
    Oncotarget  2018;9(1):982
  2. Organoid culture systems for prostate epithelial and cancer tissue.
    Authors: Drost Et al.
    Proc Natl Acad Sci U S A  2016;11:347
  3. Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity.
    Authors: Gonnermann Et al.
    Oncoimmunology  2015;4:e988460
  4. Organoid models of human and mouse ductal pancreatic cancer.
    Authors: Boj Et al.
    Sci Signal  2015;160:324
  5. In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
    Authors: Bartfeld Et al.
    Nat Protoc  2015;148:126
  6. Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases.
    Authors: Weeber Et al.
    Cell  2015;112:13308
  7. MDMA increases glutamate release and reduces parvalbumin-positive GABAergic cells in the dorsal hippocampus of the rat: role of cyclooxygenase.
    Authors: Anneken Et al.
    Respir Res  2013;8:58
  8. Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+.
    Authors: Wang Et al.
    J Neuroimmune Pharmacol  2012;5:ra26

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