Recombinant Human beta-Synuclein Active, Monomer Protein

Name: Recombinant Human beta-Synuclein Active, Monomer Protein
Brand: Novus Biologicals
SKU: NBP3-14775
Price: 499 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-14775

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Product Specifications
Scientific Data
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Applications

Western Blot, Functional Assay, SDS-PAGE

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Product Specifications

Description

A full length recombinant protein of Human beta-Synuclein

Source: E. coli

Uniprot ID: Q16143

Purity

>95%, by SDS-PAGE

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human beta-Synuclein Active, Monomer Protein

In vitro assay: Recombinant Human beta-Synuclein Active, Monomer Protein [NBP3-14775]

In vitro assay: Recombinant Human beta-Synuclein Active, Monomer Protein [NBP3-14775] - Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in alpha synuclein and beta synuclein fibrils. Beta synuclein lacks the NAC domain so its fibrils do not seed alpha synuclein or beta synuclein monomers.

SDS-PAGE: Recombinant Human beta-Synuclein Active, Monomer Protein [NBP3-14775]

SDS-Page: Recombinant Human beta-Synuclein Active, Monomer Protein [NBP3-14775] - Coomassie gel stain of Human Beta Synuclein Monomer (NBP3-14775). Load: 2 ug.

Formulation, Preparation, and Storage

NBP3-14775

Preparation Method	Ion-exchange Purified
Formulation	PBS pH 7.4
Preservative	No Preservative
Concentration	Please see the vial label for concentration. If unlisted please contact technical services.
Shipping	The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at -80C. Avoid freeze-thaw cycles.

Background: beta-Synuclein

Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function (1).

Alternate Names

SNCB, Synuclein-beta

Gene Symbol

SNCB

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Product Specific Notices for Recombinant Human beta-Synuclein Active, Monomer Protein

Please note that the 200ug and 500ug sizes are sent in 2x100ug and 5x100ug vials, respectively

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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