Betulinic acid

Key Product Details

Product Description

Betulinic acid is a natural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF-κB. Also a GPBA receptor partial agonist (EC₅₀ = 1.04 μM, efficacy 83%). Betulinic acid suppresses areobic glycolysis by regulating the Cav-1/NF-κB/c-Myc pathway in and inhibits growth in breast cancer cells.

Product Specifications for Betulinic acid

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Betulinic acid

The following data is based on the product molecular weight 456.70.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.38 mL	21.90 mL	43.79 mL
2.5 mM	0.88 mL	4.38 mL	8.76 mL
5 mM	0.44 mL	2.19 mL	4.38 mL
25 mM	0.09 mL	0.44 mL	0.88 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

• Jiao Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-?B/c-Myc pathway. Biochem.Pharmacol. 2019 PMID: 30684465
• Fulda Betulinic acid for cancer treatment and prevention. Int.J.Mol.Sci. 2008 PMID: 19325847
• Genet Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. J.Med.Chem. 2010 PMID: 19911773
• Kashiwada Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents. J.Med.Chem. 1996 PMID: 8676334

Product Documents for Betulinic acid