Natural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF-κ
B. Also a GPBA receptor partial agonist (EC50
= 1.04 μ
M, efficacy 83%).
Soluble to 50 mM in DMSO
Store at +4°C
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All Tocris products are intended for laboratory research use only.
Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes.
Genet et al.
Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents.
Kashiwada et al.
Betulinic acid for cancer treatment and prevention.
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