hh Betulinic acid (CAS 472-15-1): R&D Systems
Catalog Number: 3906
Chemical Name: (+)-(3β)-3-Hydroxylup-20(29)-en-28-oic acid
Biological Activity
Natural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF-κB. Also a GPBA receptor partial agonist (EC50 = 1.04 μM, efficacy 83%).
Technical Data
  • M.Wt:
    456.7
  • Formula:
    C30H48O3
  • Solubility:
    Soluble to 50 mM in DMSO
  • Storage:
    Store at +4°C
  • CAS No:
    472-15-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes.
    Genet et al.
    J.Med.Chem., 2010;53:178
  2. Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents.
    Kashiwada et al.
    J.Med.Chem., 1996;39:1016
  3. Betulinic acid for cancer treatment and prevention.
    Fulda
    Int.J.Mol.Sci., 2008;9:1096
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Betulinic acid include:

1 Citations: Showing 1 - 1

  1. Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum.
    Authors: Inoue Et al.
    Neurotox Res 2012;303:G810

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