Chemical Name: (+)-(3β)-3-Hydroxylup-20(29)-en-28-oic acid
Biological ActivityBetulinic acid is a natural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF-κB. Also a GPBA receptor partial agonist (EC50 = 1.04 μM, efficacy 83%). Betulinic acid suppresses areobic glycolysis by regulating the Cav-1/NF-κB/c-Myc pathway in and inhibits growth in breast cancer cells.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes.
Genet et al.
Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents.
Kashiwada et al.
Betulinic acid for cancer treatment and prevention.
Citation for Betulinic acid
The citations listed below are publications that use Tocris products. Selected citations for Betulinic acid include:
1 Citation: Showing 1 - 1
Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum.
Authors: Inoue Et al.
Neurotox Res 2012;303:G810
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