Catalog Number: 3326
Chemical Name: 5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine
Biological Activity
Selective, high affinity 5-HT6 antagonist (Ki = 20 nM). Reverses the amnesic effects of scopolamine (Cat. No. 1414) and enhances memory consolidation in a rat model.
Technical Data
  • M.Wt:
    294.39
  • Formula:
    C19H22N2O
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    17375-63-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism.
    Mitchell et al.
    Neuropharmacology, 2006;50:412
  2. 2-Substituted tryptamines: Agents with selectivity for 5-HT6 serotonin receptors.
    Glennon et al.
    J.Med.Chem., 2000;43:1011

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