Chemical Name: 1,3-Dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-2H-indol-2-one
Biological ActivityBHPI is an estrogen receptor (ER) α inhibitor. Inhibits proliferation of drug-resistant ERα-positive breast and ovarian cancer cells. Induces sustained activation of the unfolded protein response. Active in vivo.
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Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression.
Andruska et al.
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