BI 605906

Tocris Bioscience | Catalog # 5300

Selective IKKβ inhibitor
Tocris Bioscience
Discontinued Product
5300 has been discontinued. An alternative/replacement product is available: 2559. View all IkB Kinase Inhibitors products.

Key Product Details

Description

Selective IKKβ inhibitor
View all IkB Kinase Inhibitors »

Product Description

BI 605906 is a selective IKKβ inhibitor (IC50 = 380 nM). Displays no effect on a panel of 100 kinases, except at IGF1 (IC50 = 7.6 μM).

External Portal Information

The Chemical Probes webpages of the Structural Genomics Consortium are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BI 605906 is reviewed on the chemical probes website.

Product Specifications for BI 605906

Molecular Weight

432.51

Formula

C17H22F2N4O3S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-Amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]thieno[2,3-b]pyridine-2-carboxamide

CAS Number

960293-88-3

PubChem ID

23652660

InChI Key

IYHHRZBKXXKDDY-UHFFFAOYSA-N

SMILES

CS(C(CC3)CCN3C1=CC(C(CC)(F)F)=C(C(N)=C(C(N)=O)S2)C2=N1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.25 100

Preparing Stock Solutions for BI 605906

The following data is based on the product molecular weight 432.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.56 mL 23.12 mL
5 mM 0.46 mL 2.31 mL 4.62 mL
10 mM 0.23 mL 1.16 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 20 publications citing the usage of this product.

Product Documents for BI 605906

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BI 605906

For research use only

Customer Reviews for BI 605906 (1)

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  • BI 605906 protects macrophages against LPS-induced inflammation
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Macrophages
    Verified Customer | Posted 12/11/2018
    RAW macrophages were incubated with 5 μM BI 605906 for 30 min prior to addition of 200 ng/ml LPS for 8 h to follow TNFa mRNA expression. LPS elevated TNFa mRNA levels that was significantly inhibited by pretreatment of cells with BI 605906.
    BI 605906 5300

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