Catalog Number: 3314
Chemical Name: 4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-3H-1,2,4-triazol-3-one
Biological Activity
Competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. Inhibits JNK interacting protein 1 (JIP1)-JNK binding (IC50 = 500 nM) and prevents JNK substrate phosphorylation. Blocks JNK-dependent Con A-induced liver damage and restores insulin sensitivity in a mouse model of type II diabetes.
Technical Data
  • M.Wt:
    379.37
  • Formula:
    C13H9N5O5S2
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    883065-90-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of a new JNK inhibitor targeting the JNK-JIP interaction site.
    Stebbins et al.
    Proc.Natl.Acad.Sci.USA, 2008;105:16809
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BI 78D3 include:

3 Citations: Showing 1 - 3
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  1. Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury.
    Authors: Jang Et al.
    PLoS Biol 2015;6:552
  2. Effects of Y27632 on keratinocyte procurement and wound healing.
    Authors: Gandham Et al.
    Redox Biol 2013;38:782
  3. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium.
    Authors: Eckle Et al.
    Br J Pharmacol 2013;11:e1001665

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