Chemical Name: 4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-3H-1,2,4-triazol-3-one
Biological ActivityBI 78D3 is a competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. Inhibits JNK interacting protein 1 (JIP1)-JNK binding (IC50 = 500 nM) and prevents JNK substrate phosphorylation. Blocks JNK-dependent Con A-induced liver damage and restores insulin sensitivity in a mouse model of type II diabetes.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of a new JNK inhibitor targeting the JNK-JIP interaction site.
Stebbins et al.
Getting rid of JNK.
Nat.Rev.Drug Disc., 2008;7:975
Block JNK at the dock.
Haas and Writer
Citations for BI 78D3
The citations listed below are publications that use Tocris products. Selected citations for BI 78D3 include:
4 Citations: Showing 1 - 4
ERK2 phosphorylates Krüppel-like factor 8 protein at serine 48 to maintain its stability.
Authors: Lahiri Et al.
Am J Cancer Res 2016;6:910
Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury.
Authors: Jang Et al.
PLoS Biol 2015;6:552
Effects of Y27632 on keratinocyte procurement and wound healing.
Authors: Gandham Et al.
Redox Biol 2013;38:782
HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium.
Authors: Eckle Et al.
Br J Pharmacol 2013;11:e1001665
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for BI 78D3
There are currently no reviews for this product. Be the first to review BI 78D3 and earn rewards!
Have you used BI 78D3?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image