BI 78D3

Catalog # Availability Size / Price Qty
3314/10
3314/50
BI 78D3 | CAS No. 883065-90-5 | JNK/c-jun Inhibitors
1 Image
Description: Selective, competitive JNK inhibitor

Chemical Name: 4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-3H-1,2,4-triazol-3-one

Purity: ≥99%

Product Details
Citations (4)
Reviews

Biological Activity

Competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. Inhibits JNK interacting protein 1 (JIP1)-JNK binding (IC50 = 500 nM) and prevents JNK substrate phosphorylation. Blocks JNK-dependent Con A-induced liver damage and restores insulin sensitivity in a mouse model of type II diabetes.

Technical Data

M.Wt:
379.37
Formula:
C13H9N5O5S2
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
883065-90-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of a new JNK inhibitor targeting the JNK-JIP interaction site.
    Stebbins et al.
    Proc.Natl.Acad.Sci.USA, 2008;105:16809
  2. Getting rid of JNK.
    Flight
    Nat.Rev.Drug Disc., 2008;7:975
  3. Block JNK at the dock.
    Haas and Writer
    SCiBX, 2008;1:1

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for BI 78D3

The citations listed below are publications that use Tocris products. Selected citations for BI 78D3 include:

4 Citations: Showing 1 - 4

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for BI 78D3

There are currently no reviews for this product. Be the first to review BI 78D3 and earn rewards!

Have you used BI 78D3?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.