Chemical Name: 4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-3H-1,2,4-triazol-3-one
Biological ActivityCompetitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. Inhibits JNK interacting protein 1 (JIP1)-JNK binding (IC50 = 500 nM) and prevents JNK substrate phosphorylation. Blocks JNK-dependent Con A-induced liver damage and restores insulin sensitivity in a mouse model of type II diabetes.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of a new JNK inhibitor targeting the JNK-JIP interaction site.
Stebbins et al.
Getting rid of JNK.
Nat.Rev.Drug Disc., 2008;7:975
Block JNK at the dock.
Haas and Writer
Citations for BI 78D3
The citations listed below are publications that use Tocris products. Selected citations for BI 78D3 include:
4 Citations: Showing 1 - 4
ERK2 phosphorylates Krüppel-like factor 8 protein at serine 48 to maintain its stability.
Authors: Lahiri Et al.
Am J Cancer Res 2016;6:910
Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury.
Authors: Jang Et al.
PLoS Biol 2015;6:552
Effects of Y27632 on keratinocyte procurement and wound healing.
Authors: Gandham Et al.
Redox Biol 2013;38:782
HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium.
Authors: Eckle Et al.
Br J Pharmacol 2013;11:e1001665
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