Competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50
= 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. Inhibits JNK interacting protein 1 (JIP1)-JNK binding (IC50
= 500 nM) and prevents JNK substrate phosphorylation. Blocks JNK-dependent Con A-induced liver damage and restores insulin sensitivity in a mouse model of type II diabetes.
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Identification of a new JNK inhibitor targeting the JNK-JIP interaction site.
Stebbins et al.
The citations listed below are publications that use Tocris products. Selected citations for BI 78D3 include:
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