BIBP 3226 trifluoroacetate

Catalog # Availability Size / Price Qty
BIBP 3226 trifluoroacetate | NPY Receptor Antagonists
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Description: Mixed NPY Y1 and NPFF receptor antagonist

Chemical Name: N-[(1R)]-4-[(Aminoiminomethyl)amino-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl-α-phenylbenzeneacetamide trifluoroacetate

Purity: ≥98%

Product Details
Citations (14)
Supplemental Products

Biological Activity

BIBP 3226 trifluoroacetate is a mixed non-peptide neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist (Ki values are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y1, hNPFF2, rNPFF, rNPY Y2, rNPY Y4 and rNPY Y5 respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration.

Important Information

This product is sold as a TFA salt. The stoichiometry of the salt and hydration levels vary from batch to batch. This product is sold in gross weight with the batch specific Net Product Content (free base) available on the Certificate of Analysis

Technical Data

M. Wt
473.57 (Free Base)
Soluble to 1 mg/ml in water and to 50 mg/ml in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for BIBP 3226 trifluoroacetate

The citations listed below are publications that use Tocris products. Selected citations for BIBP 3226 trifluoroacetate include:

14 Citations: Showing 1 - 10

  1. Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch.
    Authors: Acton Et al.
    Cell Rep  2019;28:625
  2. Platelet Lysate-Derived Neuropeptide y Influences Migration and Angiogenesis of Human Adipose Tissue-Derived Stromal Cells.
    Authors: Businaro Et al.
    Sci Rep  2018;8(1):14365
  3. HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience.
    Authors: Ahsan Raza
    Nat Commun  2017;8(1):189
  4. Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro.
    Authors: Martins Et al.
    ASN Neuro  2015;7
  5. NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking.
    Authors: Pleil Et al.
    Nat Neurosci  2015;18:545
  6. Neuropeptide Y stimulates autophagy in hypothalamic neurons.
    Authors: Aveleira Et al.
    Cell Death Dis  2015;112:E1642
  7. High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes.
    Authors: Zacharia Et al.
    PLoS One  2013;8:e65969
  8. Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate.
    Authors: Santos-Carvalho Et al.
    Proc Natl Acad Sci U S A  2013;4:e636
  9. Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats.
    Authors: Reidelberger Et al.
    Am J Physiol Endocrinol Metab  2013;304:E944
  10. Pre-diabetes augments neuropeptide Y1- and α1-receptor control of basal hindlimb vascular tone in young ZDF rats.
    Authors: Novielli Et al.
    PLoS One  2012;7:e46659


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