Catalog Number: 2707
Chemical Name: N-[(1R)]-4-[(Aminoiminomethyl)amino-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl-α-phenylbenzeneacetamide
Biological Activity
Mixed non-peptide neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist (Ki values are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y1, hNPFF2, rNPFF, rNPY Y2, rNPY Y4 and rNPY Y5 respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration.
Important Information
This product is sold as a TFA salt. The exact stoichiometry of the salt is batch dependant.
Technical Data
  • M.Wt:
    473.57
  • Formula:
    C27H31N5O3.2CF3CO2H
  • Solubility:
    Soluble to 10 mM in water with sonication and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226: antagonism with diazepam.
    Kask et al.
    Eur.J.Pharmacol., 1996;317:R3
  2. Agonist and antagonist activities on human NPFF2 receptors of the NPY ligands GR231118 and BIBP3226.
    Mollereau et al.
    Br.J.Pharmacol., 2001;133:1
  3. In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor antagonist.
    Fang et al.
    Peptides, 2006;27:2207
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BIBP 3226 trifluoroacetate include:

10 Citations: Showing 1 - 10
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  1. Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro.
    Authors: Martins Et al.
    ASN Neuro 2015;7
  2. NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking.
    Authors: Pleil Et al.
    Nat Neurosci 2015;18:545
  3. Neuropeptide Y stimulates autophagy in hypothalamic neurons.
    Authors: Aveleira Et al.
    Cell Death Dis 2015;112:E1642
  4. High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes.
    Authors: Zacharia Et al.
    PLoS One 2013;8:e65969
  5. Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate.
    Authors: Santos-Carvalho Et al.
    Proc Natl Acad Sci U S A 2013;4:e636
  6. Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats.
    Authors: Reidelberger Et al.
    Am J Physiol Endocrinol Metab 2013;304:E944
  7. Pre-diabetes augments neuropeptide Y1- and α1-receptor control of basal hindlimb vascular tone in young ZDF rats.
    Authors: Novielli Et al.
    PLoS One 2012;7:e46659
  8. Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice.
    Authors: Pleil Et al.
    Neuropharmacology 2012;62:1777
  9. Glucocorticoid signaling in the arcuate nucleus modulates hepatic insulin sensitivity.
    Authors: Yi Et al.
    Diabetes 2012;61:339
  10. Central neuropeptide Y modulates binge-like ethanol drinking in C57BL/6J mice via Y1 and Y2 receptors.
    Authors: Sparrow Et al.
    Proc Natl Acad Sci U S A 2012;37:1409

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