BIIE 0246 hydrochloride
Chemical Name: N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide dihydrochloride
Biological ActivityBIIE 0246 hydrochloride is a potent, selective and competitive nonpeptide antagonist for the neuropeptide Y Y2 receptor (IC50 = 15 nM). Displays > 650-fold selectivity for NPY Y2 over Y1, Y4 and Y5 receptors. Active in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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BIIE0246: a selective and high affinity neuropeptide Y Y2 receptor antagonist.
Doods et al.
BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y2 receptor antagonist.
Dumont et al.
Vascular pharmacology of BIIE0246, the first selective non-peptide neuropeptide Y Y2 receptor antagonist, in vivo.
Citation for BIIE 0246 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for BIIE 0246 hydrochloride include:
1 Citation: Showing 1 - 1
Photo-induced receptor confinement drives ligand-independent GPCR signaling.
Authors: Sanchez Et al.
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