Potent and selective NHE1 inhibitor (IC50
= 31 nM). Selective for NHE1 over NHE2 and NHE3. Prevents ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo
. Prevents phenylephrine
-induced cardiomyocyte hypertrophy in vitro
, and attenuates cardiac hypertrophy and left ventricular dysfunction postinfarction in rats. Orally bioavailable.
Soluble to 50 mM in DMSO
Desiccate at RT
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All Tocris products are intended for laboratory research use only.
Early and transient sodium-hydrogen exchanger isoform 1 inhibition attenuates subsequent cardiac hypertrophy and heart failure following coronary artery ligation.
Kilić et al.
Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat.
Huber et al.