BIX NHE1 inhibitor

Catalog # Availability Size / Price Qty
5512/10
5512/50
Cat.No. 5512 - BIX NHE1 inhibitor | C16H19F3N4O2.HCl | CAS No. 1204329-34-9
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Description: Potent and selective NHE1 inhibitor

Chemical Name: 4-(1-Acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)benzamide hydrochloride

Purity: ≥98%

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Biological Activity

Potent and selective NHE1 inhibitor (IC50 = 31 nM). Selective for NHE1 over NHE2 and NHE3. Prevents ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo. Prevents phenylephrine-induced cardiomyocyte hypertrophy in vitro, and attenuates cardiac hypertrophy and left ventricular dysfunction postinfarction in rats. Orally bioavailable.

Technical Data

M.Wt:
392.8
Formula:
C16H19F3N4O2.HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1204329-34-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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