BIX NHE1 inhibitor

Key Product Details

Product Description

BIX NHE1 inhibitor is a potent and selective NHE1 inhibitor (IC₅₀ = 31 nM). Selective for NHE1 over NHE2 and NHE3. Prevents ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo. Prevents phenylephrine-induced cardiomyocyte hypertrophy in vitro, and attenuates cardiac hypertrophy and left ventricular dysfunction postinfarction in rats. Orally bioavailable.

Product Specifications for BIX NHE1 inhibitor

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BIX NHE1 inhibitor

The following data is based on the product molecular weight 392.80.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.09 mL	25.46 mL	50.92 mL
2.5 mM	1.02 mL	5.09 mL	10.18 mL
5 mM	0.51 mL	2.55 mL	5.09 mL
25 mM	0.10 mL	0.51 mL	1.02 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Huber Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat. J.Med.Chem. 2012 PMID: 22803959
• Kilić Early and transient sodium-hydrogen exchanger isoform 1 inhibition attenuates subsequent cardiac hypertrophy and heart failure following coronary artery ligation. J.Pharmacol.Exp.Ther. 2014 PMID: 25216745

Product Documents for BIX NHE1 inhibitor