Chemical Name: 1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3,5-dimethyl ester L-Lactate
Biological ActivityPotent, competitive neuropeptide (NPY) Y1 antagonist (Ki = 3.3 nM, IC50 = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ1, α1, Y2, Y4 and Y5 receptors respectively. Reduces food intake and body weight via central Y1 inhibition and is brain penetrant.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Dihydropyridine neuropeptide Y Y1 receptor antagonists 2: bioisosteric urea replacements
Poindexter et al.
Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y1 receptor antagonist
Antal-Zimanyi et al.
Dihydropyridine neuropeptide Y Y1 receptor antagonists.
Poindexter et al.
Citation for BMS 193885
The citations listed below are publications that use Tocris products. Selected citations for BMS 193885 include:
1 Citation: Showing 1 - 1
Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch.
Authors: Acton Et al.
Cell Rep 2019;28:625
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