Chemical Name: 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide
Biological ActivityBMS 303141 is an ATP citrate lyase (ACL) inhibitor (IC50 = 0.13 μM for human recombinant ACL); blocks lipid synthesis (IC50 = 8 μM in HepG2 cells). Displays no cytotoxicity up to a concentration of 50 μM. Lowers plasma glucose and triglycerides in a mouse model of hyperlipidemia. Orally bioavailable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors.
Li et al.
A novel direct homogeneous assay for ATP citrate lyase.
Ma et al.
J.Lipid Res., 2009;50:2131
Citations for BMS 303141
The citations listed below are publications that use Tocris products. Selected citations for BMS 303141 include:
3 Citations: Showing 1 - 3
Tricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns.
Authors: Márquez Et al.
Cell Rep 2019;27:525
Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase.
Authors: Namgaladze Et al.
Front Immunol 2018;9:2858
Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism.
Authors: Shah Et al.
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