BMS 303141

  ( 1 citations )    
Product Datasheet
Catalog Number:4609
Chemical Name:3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide
Product Details
Citations (1)
Reviews
Biological Activity
ATP citrate lyase (ACL) inhibitor (IC50 = 0.13 μM for human recombinant ACL); blocks lipid synthesis (IC50 = 8 μM in HepG2 cells). Displays no cytotoxicity up to a concentration of 50 μM. Lowers plasma glucose and triglycerides in a mouse model of hyperlipidemia. Orally bioavailable.
Technical Data
  • M.Wt:
    424.3
  • Formula:
    C19H15Cl2NO4S
  • Solubility:
    Soluble to 10 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    943962-47-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BMS 303141 include:

1 Citations: Showing 1 - 1

  1. Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism.
    Authors: Shah Et al.
    Oncotarget  2016;7:43713

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