Potent inosine monophosphate dehydrogenase (IMPDH) inhibitor (IC50
= 17 nM). Inhibits proliferation of human T-lymphoblasts and PBMCs in vitro
. Reduces paw swelling in a rat adjuvant arthritis model. Orally available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).
Watterson et al.