Catalog Number: 3410
Chemical Name: 3-Fluoro-4-[[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-2-naphthalenyl)acetyl]amino]-benzoic acid
Biological Activity
Selective RARγ agonist (EC50 values are 30 and 1000 nM at RARγ and RARβ respectively). Displays no activity at RARα receptors.
Technical Data
  • M.Wt:
    399.46
  • Formula:
    C23H26FNO4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Store at +4°C
  • CAS No:
    185629-22-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor γ and retinoid X receptor α.
    Abu-Abed et al.
    J.Biol.Chem., 1998;273:2409
  2. Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts.
    Taneja et al.
    Proc.Natl.Acad.Sci.USA, 1996;93:6197
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BMS 961 include:

2 Citations: Showing 1 - 2
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  1. ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
    Authors: Chronopoulos Et al.
    Nature Communications 2016;7:12630
  2. Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression.
    Authors: Centritto Et al.
    PLoS Pathog 2015;7:950

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