Chemical Name: 3-Fluoro-4-[[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-2-naphthalenyl)acetyl]amino]-benzoic acid
Biological ActivityBMS 961 is a selective RARγ agonist (EC50 values are 30 and 1000 nM at RARγ and RARβ respectively). Displays no activity at RARα receptors.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts.
Taneja et al.
Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor γ and retinoid X receptor α.
Abu-Abed et al.
Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARγ.
Klaholz et al.
Citations for BMS 961
The citations listed below are publications that use Tocris products. Selected citations for BMS 961 include:
3 Citations: Showing 1 - 3
Effects of retinoic acid receptor-γ on the Aspergillus fumigatus induced innate immunity response in human corneal epithelial cells.
Authors: Wang Et al.
Int J Ophthalmol 2016;9:1713
ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
Authors: Chronopoulos Et al.
Nature Communications 2016;7:12630
Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression.
Authors: Centritto Et al.
PLoS Pathog 2015;7:950
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