BMS 961

Catalog # Availability Size / Price Qty
BMS 961 | CAS No. 185629-22-5 | Retinoic Acid Receptor Agonists
1 Image
Description: Selective RARγ agonist

Chemical Name: 3-Fluoro-4-[[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-2-naphthalenyl)acetyl]amino]-benzoic acid

Purity: ≥97%

Product Details
Citations (3)

Biological Activity

BMS 961 is a selective RARγ agonist (EC50 values are 30 and 1000 nM at RARγ and RARβ respectively). Displays no activity at RARα receptors.

Technical Data

Soluble to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Retinoids induce integrin-independent lymphocyte adhesion through RAR-alpha nuclear receptor activity.
    Whelan J, Wang L, Chen J, Metts M, Nasser T, McGoldrick L, Bridges L
    Biochem Biophys Res Commun, 2014;454(4):537-542.
  2. Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts.
    Taneja et al.
    Proc.Natl.Acad.Sci.USA, 1996;93:6197
  3. Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor γ and retinoid X receptor α.
    Abu-Abed et al.
    J.Biol.Chem., 1998;273:2409
  4. Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARγ.
    Klaholz et al.
    Proc.Natl.Acad.Sci., 2000;97:6322

Product Datasheets

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Citations for BMS 961

The citations listed below are publications that use Tocris products. Selected citations for BMS 961 include:

3 Citations: Showing 1 - 3


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