High affinity CCR2 chemokine receptor antagonist (IC50
= 5.1 nM). Displays potent functional antagonism, IC50
values are 1 and 18 nM for chemotaxis and antagonism of calcium flux respectively. Selective over CCR3.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists.
Cherney et al.
CCR2 receptor ligands inhibit Cav3.2 T-type calcium channels.
You et al.
The citations listed below are publications that use Tocris products. Selected citations for BMS CCR2 22 include:
Showing Results 1 - 1 of 1