BMS CCR2 22
Chemical Name: 2-[(Isopropylaminocarbonyl)amino]-N-[2-[[cis-2-[[4-(methylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Biological ActivityBMS CCR2 22 is a high affinity CCR2 chemokine receptor antagonist (IC50 = 5.1 nM). Displays potent functional antagonism, IC50 values are 1 and 18 nM for chemotaxis and antagonism of calcium flux respectively. Selective over CCR3.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists.
Cherney et al.
CCR2 receptor ligands inhibit Cav3.2 T-type calcium channels.
You et al.
Citations for BMS CCR2 22
The citations listed below are publications that use Tocris products. Selected citations for BMS CCR2 22 include:
3 Citations: Showing 1 - 3
Effect of CCR2 inhibitor-loaded lipid micelles on inflammatory cell migration and cardiac function after myocardial infarction.
Authors: Wang Et al.
Int J Nanomedicine 2018;13:6441
M-sec regulates polarized secretion of inflammatory endothelial chemokines and facilitates CCL2-mediated lymphocyte transendothelial migration.
Authors: Barzilai Et al.
J Leukoc Biol 2016;99:1045
CCR2 acts as scavenger for CCL2 during monocyte chemotaxis.
Authors: Volpe Et al.
PLoS One 2012;7:e37208
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