Catalog Number: 3129
Chemical Name: 2-[(Isopropylaminocarbonyl)amino]-N-[2-[[cis-2-[[4-(methylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Biological Activity
High affinity CCR2 chemokine receptor antagonist (IC50 = 5.1 nM). Displays potent functional antagonism, IC50 values are 1 and 18 nM for chemotaxis and antagonism of calcium flux respectively. Selective over CCR3.
Technical Data
  • M.Wt:
    593.66
  • Formula:
    C28H34F3N5O4S
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    445479-97-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists.
    Cherney et al.
    J.Med.Chem., 2008;51:721
  2. CCR2 receptor ligands inhibit Cav3.2 T-type calcium channels.
    You et al.
    Mol.Pharmacol., 2010;77:211
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BMS CCR2 22 include:

1 Citations: Showing 1 - 1

  1. CCR2 acts as scavenger for CCL2 during monocyte chemotaxis.
    Authors: Volpe Et al.
    PLoS One 2012;7:e37208

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